Synthesis of poly(2-hydroxypropyl methacrylate) latex particles via aqueous dispersion polymerization

RAFT Synthesis of Sterically Stabilized Methacrylic Nanolatexes and Vesicles by Aqueous Dispersion Polymerization

“…Recently, we reported the use of conventional (nonliving) free radical chemistry for the aqueous dispersion polymerization of a commodity methacrylic monomer, 2hydroxypropyl methacrylate (HPMA). [41] The resulting PHPMA latexes were stabilized by poly(N-vinylpyrrolidone) and the mean particle diameter could be varied from approximately 100 to 1000 nm diameter, with good control over the particle size distribution being achieved in most cases. Herein we explore the RAFT synthesis of sterically stabilized PHPMA nanolatexes of 20 to 100 nm diameter by surfactant-free aqueous dispersion polymerization using a poly(glycerol monomethacrylate)-based chain transfer agent (CTA) as the reactive steric stabilizer.…”

“…HPMA is a relatively unusual monomer in that it is water-miscible, but the corresponding PHPMA is waterinsoluble; this is an essential criterion for aqueous dispersion polymerization. Unlike our earlier synthesis of PHPMA latexes using conventional free radical polymerization, [41] we have utilized RAFT chemistry in the present work so the resulting PHPMA latexes actually comprise PGMA 65 -PHPMA x block copolymers, since the PHPMA chains are grown from the PGMA 65 macroCTA. Initially, the growing PGMA 65 -PHPMA x block copolymer remains water-soluble since the PHPMA block is still relatively short.…”

“…HPMA monomer is known to undergo slow transesterification during storage at ambient temperature, generating a small amount of dimethacrylate species (< 0.2 mol %) with the elimination of a 1,2-propylene glycol by-product. [41] This dimethacrylate impurity can lead to a low level of crosslinking during the RAFT polymerization of HPMA. Thus the homopolymerization of HPMA in DMF by RAFT at 70 8C using CTP gave a polydispersity of 1.34 for a target degree of polymerization of 50, but a polydispersity of 1.92 for a target degree of polymerization of 300.…”

Investigating the Effectiveness of Reactive Dispersants in Non‐Aqueous Dispersion Polymerization

“…The solids content in these literature studies is normally at a significantly lower level (<20 wt%) than that used in industrial NAD formulations (50–60 wt%). Polar organic stabilizers with labile hydrogen atoms are often used in alcohol/water dispersions, such as poly(vinyl pyrrolidone), hydroxyl propyl cellulose, poly(acrylic acid), and poly(amic acid) . These dispersants can become chemically attached to the polymer particles through H‐atom abstraction by growing oligomers to form in situ grafts; a portion of the stabilizer may also be physically adsorbed onto the newly formed particles …”

Size control of highly monodisperse polystyrene particles by modified dispersion polymerization

“…Of course, APS and KPS have been used as initiators in dispersion polymerization in case of using water soluble monomers such as acrylamide and 2-hydroxypropyl methacrylate. [29][30][31][32] However, in most case they could not produce highly monodisperse particles and their usages have been restricted in aqueous dispersion polymerization.…”