RAFT Synthesis of Sterically Stabilized Methacrylic Nanolatexes and Vesicles by Aqueous Dispersion Polymerization

Li, Yuting; Armes, Steven P.

doi:10.1002/ange.201001461

Cited by 36 publications

(12 citation statements)

References 52 publications

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“…A PGMA65-b-PHPMA28 block copolymer would probably not self-assemble and if it did, would only lead to small spheres. 11,74,75 These results strongly suggests that: 1) the peculiar structures observed here are directly caused by the GFF sequences in the macro-CTA, 2) the effect of the SAP is very strong even in polymers containing an average of only seven GFF moieties per molecule, and 3) the GFF sequences are accessible and remain active during the PISA process.…”

Section: P(gma-stat-(mam-gff))-b-phpma Nano-objects Via Pisasupporting

confidence: 52%

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

et al. 2020

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Self-assembling peptides (SAP) have been extensively studied for their ability to form nanoscale ordered structures driven by non-covalent molecular interactions. Meanwhile, polymerization-induced self-assembly (PISA) has been exploited as a facile and efficient way to produce various amphiphilic block copolymer nano-objects, whose self-assembly was governed predominantly by the interactions of the different blocks with the polymerization medium. In this work, we combined PISA with SAP to prepare novel peptide-polymer hybrid nano-objects, thus harnessing the advantages of PISA and the self-assembling driving force of SAP. A tripeptide methacrylamide derivative (MAm-Gly-Phe-Phe-NH2, denoted MAm-GFF where MAm means methacrylamide) was copolymerized with glycerol monomethacrylate (GMA) to produce P(GMA65-stat-(MAm-GFF)7) macro-chain transfer agent (macro-CTA) by Reversible addition-fragmentation chain transfer (RAFT) polymerization in DMF.This peptide-based macro-CTA was then successfully chain-extended with poly(2-hydroxypropyl methacrylate) (PHPMA) by aqueous dispersion PISA, forming P(GMA65-stat-(MAm-GFF)7)-b-PHPMA28 self-assembled objects. Fibrous structures were observed by TEM and Cryo-TEM in agreement with DDLS, SLS and SAXS experiments that also revealed long anisotropic morphologies. Such structures have not been reported previously for PISA-prepared nano-objects. This confirms the decisive influence of the GFF SAP on the self-assembly. In addition, annealing the PISA suspension at different temperatures led to a significant size decrease of the self-assembled objects and to a morphological transition caused by the thermo-sensitivity of both the core-forming PHPMA block and the stabilizing P(GMAstat-(MAm-GFF)) block.

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Section: P(gma-stat-(mam-gff))-b-phpma Nano-objects Via Pisasupporting

confidence: 52%

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

et al. 2020

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“…25,26 A well-known example of an aqueous RAFT dispersion polymerization, and certainly, the most-studied, is the poly(glycerol monomethacrylate)-block-poly(2-hydroxypropyl methacrylate) (PGMA-b-PHPMA) composition (Figure 1a). 14,27,28 Here, PGMA forms the soluble stabilizer block, and PHPMA forms the insoluble nanoparticle core. Nonpolar RAFT-PISA formulations are less well-known.…”

Section: Raft-pisamentioning

confidence: 99%

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

et al. 2021

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“…14,[16][17][18] Dispersion polymerization initially involves a completely homogeneous solution. [19][20][21][22] However, the resultant polymer is not soluble in the polymerization medium. 7,23 In RAFT dispersion polymerization, a previously synthesized soluble homopolymer, a so-called macromolecular chain transfer agent (macroRAFT agent), is used as the stabilizer of the following dispersion polymerization.…”

Section: Introductionmentioning

confidence: 99%

Well-defined polyvinylpyridine-block-polystyrene diblock copolymers via RAFT aqueous-alcoholic dispersion polymerization: synthesis and isoporous thin film morphology

2021

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RAFT Synthesis of Sterically Stabilized Methacrylic Nanolatexes and Vesicles by Aqueous Dispersion Polymerization

Cited by 36 publications

References 52 publications

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

Well-defined polyvinylpyridine-block-polystyrene diblock copolymers via RAFT aqueous-alcoholic dispersion polymerization: synthesis and isoporous thin film morphology

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