Synthesis of PLGA/chitosan/zeolites and PLGA/chitosan/metal organic frameworks nanofibers for targeted delivery of Paclitaxel toward prostate cancer cells death

Dizaji, Babak Faraji; Azerbaijan, Mohammadreza Hasani; Sheisi, Niloofar; Goleij, Pouya; Mirmajidi, Tahereh; Chogan, Faraz; Irani, Mohammad; Sharafian, Fariborz

doi:10.1016/j.ijbiomac.2020.07.228

Cited by 105 publications

(29 citation statements)

References 64 publications

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“…A pronounced degraded coating and more irregular and hydrophilic surface (due to local exposure of the substrate) were favorable for abundant deposition of salts originating from the testing medium. Moreover, once attached onto the already impaired coating, inorganic salts acted as local accelerators for polymeric degradation, by promoting hydrolysis of copolymer’s ester groups due to local pH changes [ 38 , 76 ]. These observations reinforced previous IR results on the SBF-mediated hydrolysis of PLGA matrix, evidenced by a significant shift of carbonyl moiety originating either from PLGA (until 15 th day of testing) or from LA and GA units (20 and 30 days of testing).…”

Section: Resultsmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

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Section: Resultsmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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“…The articles also employed a variety of both ZIFs and natural/synthetic zeolites ( Table 1 ). Of the 53 articles included in this study, 36 studies utilized ZIFs [ 22 , 25 , 30 , 32 , 37 , 38 , 40 , 42 , 43 , 44 , 47 , 48 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 64 , 66 , 70 , 71 , 72 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ], 9 studies utilized faujasite (FAU) [ 16 , 50 , 62 , 64 , 67 , 68 , 75 , 82 , 83 ], 5 studies utilized Zeolite A/Linde Type A (LTA) [ 14 , 49 , 63 , 68 , 82 ], and 3 studies utilized clinoptilolite [ 53 , 8...…”

Section: Discussionmentioning

confidence: 99%

“…In addition to DOX, 5-FU, curcumin, cisplatin, and miR-34a, a variety of other drugs have been studied with zeolites/ZIFs acting as nanocarriers, with ZIF-8 being the most popular choice. Faraji Dizaji et al loaded Paclitaxel into zeolite (ZSM-5) and MOFs (MIL-101 and ZIF-8) and saw that the MOFs had higher loading and more sustained release of the drug compared to their zeolite counterparts [ 75 ]. ZIF-8 can also be successfully used to deliver camptothecin [ 76 ], arsenic trioxide species [ 77 ], rapamycin [ 47 ], RNase A [ 78 ], gemcitabine [ 79 ], melittin [ 80 ], and lactate oxidase & Fe 3 O 4 nanoparticles [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Hao

Milašin²,

Eken

et al. 2021

Molecules

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Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment.

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“…Chitosan was used because it is a naturally occurring polymer showing high bioactivity, biocompatibility and biodegradability. Also, chitosan, due to its high stretch characteristics and production of thinner nanofibers, could incorporate a high content of drug [placental extract] molecules (39,40) . The polylactic-co-glycolic acid is a synthetic polymer and was used to provide the blend of polymers better mechanical properties.…”

Section: Discussionmentioning

confidence: 99%

The Use of Human Placental Extract to Arrest and Restrict the Established Carious Lesions with the Aid of Nano Fibered Local Drug Delivery Systems: A Two Years' Evidence Based Study

Fares

Zahaby

2023

Egyptian Dental Journal

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The use of human placental extract as a therapeutic agent has caused revolution in the medical field .This is due to its immunomodulatory effect, numerous growth factors and powerful regenerative property. In this study we made use of these unique properties of the human placental extract in order to cause arrest of the established carious lesions. A treatment aiming at tissue healing, regeneration and thus dentinogenesis. Local drug delivery systems were used to aid in sustained, controlled and targeted release of the placental extract .Eighty patients were included in this study. The patients were divided into two groups of 40. Group (P) received the placental extract treatment and was further divided into two sub groups of 20 (Pa&Pb) according to the method of administration of the placental extract and the pharmaceutical modulation of the release and targeting process. The other group (C) was a control group and did not receive the placental extract treatment. After two weeks all patients were investigated clinically for signs and symptoms and radiographically for pathologic radiographic changes. Follow up of all patients was carried out over three and six months and two years time. Regarding group (P), sub group (Pa), except for one case, at all time periods, nineteen cases demonstrated appropriate function and normal periodontium apparatus and total absence of any clinical signs and symptoms .The same went with sub group (Pb) except for two cases. Regarding the control group (C), at all time periods, twenty one cases did not show any clinical signs symptoms and demonstrated normal periodontium apparatus. Five cases failed over six months and needed retreatment. Nine cases failed in two years and needed retreatment. While five cases failed in two years and needed traditional endodontic treatment.

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Synthesis of PLGA/chitosan/zeolites and PLGA/chitosan/metal organic frameworks nanofibers for targeted delivery of Paclitaxel toward prostate cancer cells death

Cited by 105 publications

References 64 publications

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

The Use of Human Placental Extract to Arrest and Restrict the Established Carious Lesions with the Aid of Nano Fibered Local Drug Delivery Systems: A Two Years' Evidence Based Study

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