Synthesis of phosphorylated chitosan by novel method and its characterization

Jayakumar, R.; Nagahama, Hideaki; Furuike, Tetsuya; Tamura, Hiroshi

doi:10.1016/j.ijbiomac.2007.12.011

Cited by 116 publications

(73 citation statements)

References 23 publications

(33 reference statements)

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“…This transition is due to the decreased crystalline nature of the CS/PCL scaffold compared to PCL. A broad peak was observed for CS at 40-60°C, which was due to the evaporation of moisture and hydroxyl entity from the CS structure (Jayakumar, Nagahama, Furuike, & Tamura, 2008).…”

Section: Thermal Studiesmentioning

confidence: 99%

Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture

Shalumon

Haridas

Girish

et al. 2010

Carbohydrate Polymers

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106

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Section: Thermal Studiesmentioning

confidence: 99%

Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture

Shalumon

Haridas

Girish

et al. 2010

Carbohydrate Polymers

Self Cite

201

106

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“…19 The rationale for this is that chitosan modification will keep the original physiochemical and biochemical properties of chitosan and bring the new properties of the group introduced to them at the same time. 8,11,20 The chitosan nanoparticle has received much attention from researchers which has been related to their potential application, especially in medicine. 21,22 Nanoparticle chitosan has gained growing interest due to its biodegradability, biocompatibility, high permeability, non-toxic property, cost-effectiveness and excellent film forming ability.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory Activity of Chitosan Nanoparticles on Wistar Albino Rats

Sudjarwo¹,

Mahmiah²,

Sudjarwo³

2018

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Background:The active components of natural products provide a potential alternative to conventional immunotherapy for a variety of diseases conditions and become subject to scientific investigations currently worldwide. Objective: The purpose of this research was to investigate the immunostimulatory activity of the chitosan nanoparticle on Wistar albino rats. Materials and Methods: The present investigation was carried out on various groups of healthy adult rats. The assessment of immunomodulatory potential was carried out by neutrophil adhesion test, delayed-type hypersensitivity (DTH) response, haemagglutinating antibody (HA) titre, cyclophosphamide-induced myelosuppression and phagocytic activity were determined in various groups of animals. Results: The administration of chitosan nanoparticle at doses 300 mg/kg BW and 600 mg/kg BW but not at doses 150 mg/kg BW significantly increased in neutrophil adhesion fibers, haemagglutinating antibody titre values and potentiated the inhibited type hypersensitivity reaction induced by sheep red blood cells. Also, it had good response towards phagocytosis in carbon clearance assay and prevented myelosuppression of cyclophosphamide on rats. Conclusion: From these findings, it can be concluded that chitosan nanoparticle responsible for immunostimulatory activity and has therapeutic potential for the prevention of immune depressed conditions.

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“…Phosphorylated chitosan can also be prepared by chitosan with H 3 PO 4 /Et 3 PO 4 /P 2 O 5 /hexanol as reported previously [40]. The reaction scheme is shown in Fig.…”

Section: Preparative Methods Of Phosphorylated Chitin and Chitosanmentioning

confidence: 97%