Synthesis of PEGylated chitosan copolymers as efficiently antimicrobial coatings for leather

Abstract

In this work, poly(ethylene glcycol)-grafted chitosan (PEG-g-CS) was synthesized by conjugating PEG to the chitosan (CS) backbone. Such PEGylated CS copolymer was further characterized by FTIR and 1 H NMR, and the results demonstrated the successful synthesis. After PEGylation, the water solubility of CS was significantly improved due to the hydrophilicity of the PEG polymer. Therefore, this PEGylated CS was prepared as water borne coating for leather surface. The morphology and hydrophilicity of this coating on leather was studied by SEM and water contact angle measurement. Furthermore, the antimicrobial activity of PEGylated CS coating was investigated by measuring its minimum inhibitory concentration and the inhibition zone of coated leather against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, respectively. Compared to CS coating, such PEGg-CS coating exhibited better antimicrobial property, which indicated the synergetic effect of the antimicrobial property of CS and the antiadhesive property of PEG. Thus, this PEGylated CS copolymer can be used as efficiently antimicrobial coating for leather product.

Chitosan temperature‑sensitive gel loaded with drug microspheres has excellent effectiveness, biocompatibility and safety as an ophthalmic drug delivery system

“…In addition, due to the inconvenience of night administration, the pharmacological peak-valley phenomenon is prominent, greatly affecting the treatment effect of ocular drugs. With the development of novel technologies, novel ophthalmic drug delivery systems have been designed to effectively elevate ocular bioavailability by prolonging the retention time of drugs in the eye or improving the penetration of drugs into the cornea and conjunctiva (3,4). …”

PEGylated chitosan protected silver nanoparticles as water-borne coating for leather with antibacterial property

“…The results demonstrated that PEG-gCS@AgNPs coating exhibited significant advantages in antibacterial property than that of PEG-g-CS and chitosan coating, which is consistent with the MIC results. Our previous work has proved that PEGylated chitosan (PEG-g-CS) exhibited more efficient antibacterial activity than that of singe CS coating due to the synergistic antimicrobial property of PEG and CS [5]. Wherein, the PEG component played the role in preventing the adhesion of bacteria on the coating surface while CS sustainably inhibited the growth of bacteria by contact killing.…”

“…PEG-g-CS copolymers were synthesized according to our previous report [5]. The amino substitution degree (SD) of PEG-g-CS defined as the number of PEG group per 100 amino groups of CS was determined by TNBS method [36].…”

“…To address this issue, antimicrobial coatings with excellent nonfouling property for resisting bacterial attachment and accelerating bacterial release have been developed by using hydrophilic poly(ethylene glycol) (PEG) polymer [13,[30][31][32][33]. Our previous study revealed that PEGylated chitosan (PEG-g-CS) coating exhibited more efficiently antibacterial activity than that of single chitosan coating, due to the synergistic effect between bacterial resistance of PEG and contact-killing of chitosan [5]. Dead bacteria cells could also be easily washed from the PEGylated quaternized chitosan coating reported by Chan-Park's group, and the coating preserved its antimicrobial activity even after the fourth challenge with S. aureus [13].…”

“…Therefore, the inhibition of microorganism's growth on the leather surface has been an issue of major interest, at industrial level, and forms the consumer's point of view. To solve these problems, developing environment-friendly and effectively antibacterial coating for leather becomes a feasible strategy, which can greatly reduce the bacterial proliferation and thereby prevent subsequent biofilm formation [2,5].…”