Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan andα‐Cyclodextrin

Abstract

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Preparation of mucoadhesive methacrylated chitosan nanoparticles for delivery of ciprofloxacin

“…Mucoadhesive nanoparticles are normally prepared using hydrophilic polymers as excipients in their formulations. A typical example of these polymers is chitosan which is a cationic polysaccharide with unique properties including hydrophilicity, safety, biodegradability, drug permeation-enhancing ability, and mucoadhesivity [28,29]. The main mechanism involved in the mucoadhesion of chitosan is the electrostatic attraction between chitosan and the mucin glycoproteins of mucus on mucosal surfaces [30][31][32].…”

Self-Healing Hydrogels: From Synthesis to Multiple Applications

“…PEG-grafted chitosan and α-cyclodextrin were also combined to fabricate dynamic hydrogels with shear-thinning properties. 145 Schiff-base bonds are introduced into slide-ring polymer systems to prepare polyrotaxane-based self-healing hydrogels. Hydroxypropylated polyrotaxane-bearing aldehydes were cross-linked with glycol chitosan via Schiff-base reaction to form polyrotaxane-based self-healing hydrogels with high mechanical toughness.…”

“…The hydrogel can be applied to load donepezil drug, which realized sustained drug delivery. PEG-grafted chitosan and α-cyclodextrin were also combined to fabricate dynamic hydrogels with shear-thinning properties . Furthermore, Schiff-base bonds are introduced into slide-ring polymer systems to prepare polyrotaxane-based self-healing hydrogels.…”