Synthesis of Pectin and Eggshell Biowaste-Mediated Nano-hydroxyapatite (nHAp), Their Physicochemical Characterizations, and Use as Antibacterial Material

Thakur, Priyanka; Arivarasan, Vishnu Kirthi; Kumar, Gaurav; Pant, Gaurav; Kumar, Rohit; Pandit, Soumya; Pant, Manu; Singh, Anjuvan; Gupta, Piyush Kumar

doi:10.1007/s12010-023-04550-6

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…Titanium-, gold-, silver-, and copper-based nanoparticles have been widely analyzed for antibacterial and antibiofilm effectiveness . These metal-oxide nanoparticles enter the cell mostly via electrostatic attraction, accumulate, and lead to ROS generation causing cell membrane disruption, protein photo-oxidation, and inhibition of enzyme activity and generating superoxide radicals. − Though metal nanoparticles of gold, silver, titanium oxide, and zinc oxide have shown good antimicrobial properties, concerns about their biocompatibility , have limited their use, and carbon-based nanomaterials are being greatly explored. , After the accidental discovery of CDs in 2004, these minuscule particles have gained considerable attention because of their superior optical properties, photostability, aqueous solubility, and biocompatibility. ,− CDs are zero-dimensional quantum dots with a size below 10 nm comprising a carbon core and a surface passivation layer. The carbon in the core structure is either sp 2 or sp 3 hybridized carbon.…”

Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Priyadarshini,

Kumar,

Balakrishnan

et al. 2024

ACS Appl. Bio Mater.

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Biofilms are an intricate community of microbes that colonize solid surfaces, communicating via a quorum-sensing mechanism. These microbial aggregates secrete exopolysaccharides facilitating adhesion and conferring resistance to drugs and antimicrobial agents. The escalating global concern over biofilm-related infections on medical devices underscores the severe threat to human health. Carbon dots (CDs) have emerged as a promising substrate to combat microbes and disrupt biofilm matrices. Their numerous advantages such as facile surface functionalization and specific antimicrobial properties, position them as innovative anti-biofilm agents. Due to their minuscule size, CDs can penetrate microbial cells, inhibiting growth via cytoplasmic leakage, reactive oxygen species (ROS) generation, and genetic material fragmentation. Research has demonstrated the efficacy of CDs in inhibiting biofilms formed by key pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Consequently, the development of CD-based coatings and hydrogels holds promise for eradicating biofilm formation, thereby enhancing treatment efficacy, reducing clinical expenses, and minimizing the need for implant revision surgeries. This review provides insights into the mechanisms of biofilm formation on implants, surveys major biofilm-forming pathogens and associated infections, and specifically highlights the anti-biofilm properties of CDs emphasizing their potential as coatings on medical implants.

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Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Priyadarshini,

Kumar,

Balakrishnan

et al. 2024

ACS Appl. Bio Mater.

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“…Metallopolymer nanocomposites are hybrid nanomaterials that combine metal components' electrical, optical, catalytic, and thermal properties with the polymer component's flexibility, solubility, and manufacturability. 90−93 biomedical applications 94 because of their superior properties. Silver NP−polyvinylpyrrolidone−[meglumine antimoniate (Glucantime)]) nanocomposite, abbreviated as Ag NPs-PVP-MA, exhibited considerable antileishmanial activity against Leishmania amazonensis infection in vitro.…”

Section: Metal and Metal Oxidesmentioning

confidence: 99%

Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review

Tambe,

Nag,

Pandya

et al. 2024

ACS Infect. Dis.

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Leishmaniasis, one of the most overlooked tropical diseases, is a life-threatening illness caused by the parasite Leishmania donovani that is prevalent in underdeveloped nations. Over 350 million individuals in more than 90 different nations worldwide are at risk of contracting the disease, which has a current fatality rate of 50 000 mortalities each year. The administration of liposomal Amp B, pentavalent antimonials, and miltefosine are still considered integral components of the chemotherapy regimen. Antileishmanial medications fail to treat leishmaniasis because of their numerous drawbacks. These include inadequate effectiveness, toxicity, undesired side effects, drug resistance, treatment duration, and cost. Consequently, there is a need to overcome the limitations of conventional therapeutics. Nanotechnology has demonstrated promising outcomes in addressing these issues because of its small size and distinctive characteristics, such as enhanced bioavailability, lower toxicity, biodegradability, and targeted drug delivery. This review is an effort to highlight the recent progress in various nanodrug delivery systems (nDDSs) over the past five years for treating leishmaniasis. Although the preclinical outcomes of nDDSs have shown promising treatment for leishmaniasis, further research is needed for their clinical translation. Advancement in three primary priority domains�molecular diagnostics, clinical investigation, and knowledge dissemination and standardization�is imperative to propel the leishmaniasis field toward translational outcomes.

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“…A few examples of such NPs are ZnFe 2 O 4 , MnFe 2 O 4 , ZnO, Fe 3 O 4 , Fe 2 O 4 , CuO, ZnO, Ag, Cu, and Au. , These NPs possess surface plasmon resonance properties and are flexible in surface functionalization. Furthermore, their biocompatible nature leads to their broader use as anticancer, antibacterial, antiviral, antifungal, anti-insecticidal, antiprotozoans, or antileishmanial activities. − Moreover, the use of M/MO NPs has been limited due to their slower degradation and aggregation properties. Therefore, to overcome such limitations, M/MO NPs were coated with polymers to develop nanocomposite for enhancing their physicochemical properties. , Due to this, these hybrid NMs can be utilized broadly for healthcare and environmental applications further.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 These NPs possess surface plasmon resonance properties and are flexible in surface functionalization. Furthermore, their biocompatible nature leads to their broader use as anticancer, antibacterial, 8 antiviral, antifungal, anti-insecticidal, antiprotozoans, or antileishmanial activities. 9−11 Moreover, the use of M/MO NPs has been limited due to their slower degradation and aggregation properties.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

Chauhan,

Naik,

Kumar

et al. 2024

ACS Omega

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Recently, the use of hybrid nanomaterials (NMs)/nanocomposites has widely increased for the health, energy, and environment sectors due to their improved physicochemical properties and reduced aggregation behavior. However, prior to their use in such sectors, it is mandatory to study their toxicological behavior in detail. In the present study, a ZnFe 2 O 4 @poly(tBGE-alt-PA) nanocomposite is tested to study its toxicological effects on a fruit fly model. This nanocomposite was synthesized earlier by our group and physicochemically characterized using different techniques. In this study, various neurological, developmental, genotoxic, and morphological tests were carried out to investigate the toxic effects of nanocomposite on Drosophila melanogaster. As a result, an abnormal crawling speed of third instar larvae and a change in the climbing behavior of treated flies were observed, suggesting a neurological disorder in the fruit flies. DAPI and DCFH-DA dyes analyzed the abnormalities in the larva's gut of fruit flies. Furthermore, the deformities were also seen in the wings and eyes of the treated flies. These obtained results suggested that the ZnFe 2 O 4 @poly(tBGE-alt-PA) nanocomposite is toxic to fruit flies. Moreover, this is essential to analyze the toxicity of this hybrid NM again in a rodent model in the future.

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Synthesis of Pectin and Eggshell Biowaste-Mediated Nano-hydroxyapatite (nHAp), Their Physicochemical Characterizations, and Use as Antibacterial Material

Cited by 4 publications

References 32 publications

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

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Synthesis of Pectin and Eggshell Biowaste-Mediated Nano-hydroxyapatite (nHAp), Their Physicochemical Characterizations, and Use as Antibacterial Material

Cited by 4 publications

References 32 publications

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review

In Vivo Toxicological Analysis of the ZnFe2O4@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

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In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly