Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines

Abstract

A new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.

The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds

“…Mononuclear complexes of the general formula [Ru( 5 The formulation and purity of all the new compounds is supported by analytical data, FT-IR spectroscopy, 1 H, 13 C, 31 [17][18][19][20]. The positive shift in the  S=O of ca.…”

Anticancer Activities of Mononuclear Ruthenium(II) Coordination Complexes

“…There is remarkable prospective among ruthenium half-sandwich structured complexes with cyclopentadienyl ligands [47][48][49]. The aromatic ligand 5 -C 5 H 5 occupies three coordination positions, thereby offering stability to the metal centre [47].…”

A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites

“…Final DNA concentration per nucleotide was determined by UV absorption spectroscopy using molar absorption coefficient of 6600 M -1 cm -1 at 260 nm [76]. [33]. b From reference [58].…”

“…In this perspective, ruthenium-cyclopentadienyl complexes presenting N-heteroaromatic ligands have exhibited excellent antitumoral properties and are very promising agents for cancer therapy [30][31][32][33][34]. In addition, ruthenium classical coordination compounds and organometallic compounds have been recognized as prospective agents against trypanosomatid parasites [35][36][37][38][39][40][41][42].…”