“…Poly( N -isopropylacrylamide), PNIPAM , is as a well-known thermo-responsive polymer and displays significant physical property changes with temperature. − Lower critical solution temperature (LCST) in aqueous solution is an important characteristic parameter of this polymer. ,, Below the temperature 32 °C, PNIPAM is soluble in water and is found in an expanded conformation, whereas above, it dehydrates, to a certain extent, becoming insoluble and forming aggregates. , PNIPAM can establish hydrogen bonds, both with water and with other PNIPAM repeat units . The LCST behavior of PNIPAM has been attributed to the delicate balance between hydrogen bonding with water and hydrophobic hydration. − Despite the fact that this change from expanded to compact (aggregate-like), with the characteristic LCST is known since 1968, with its synthesis made 12 years before, it still shows a deep interest namely because of the many applications − of this polymer, but also because the transition phase phenomena shown by this polymer, that remains mysterious, with some claims that the PNIPAM structure in solution is still to be solved …”