Preparation of PNIPAM-Azo by RAFT polymerization and their application in thermo- and light-responsive hydrogel

Li, Dongxiang; Xing, Qinghe; Huang, Rui; Li, Chunfang

doi:10.1007/s10965-023-03541-9

Cited by 2 publications

(6 citation statements)

References 34 publications

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“…Activation-modulated systems utilize specific triggers or stimuli to initiate drug release at the target site [32,79,80]. The triggers can be external, such as light [121][122][123], heat [124,125], or magnetic fields [126][127][128], or internal [63], including changes in pH [76][77][78]129,130], temperature [131,132], enzyme levels [24,76,132], or redox conditions [11,16,29]. By incorporating responsive materials or incorporating stimuli-responsive components, these systems enable a precise control over drug release, ensuring that the drug is delivered when and where it is needed most [56,70].…”

Section: Activation-modulated Drug Delivery Systemmentioning

confidence: 99%

“…Light-responsive polymer-based hydrogels, also known as photoresponsive or photosensitive hydrogels, are a type of hydrogel that can undergo changes in their properties or behavior upon exposure to light [121][122][123]. These hydrogels contain light-sensitive components or photoactive molecules that can be activated or deactivated by specific wavelengths of light [121].…”

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

“…These hydrogels contain light-sensitive components or photoactive molecules that can be activated or deactivated by specific wavelengths of light [121]. Light-responsive polymer-based hydrogels can be classified into two main categories of photothermal-responsive polymer-based hydrogels and photoresponsive polymer-based hydrogels [122]. The first one exhibits a response to light in the form of heat generation.…”

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

“…This response is achieved through the incorporation of photoresponsive molecules, such as photochromic compounds or light-sensitive crosslinkers, into the polymer network [11]. These molecules undergo reversible photoisomerization or photodimerization reactions when illuminated with specific wavelengths of light, leading to conformational changes or crosslinking/de-crosslinking of the polymer network [23,122]. Light-responsive polymer-based hydrogels offer precise spatiotemporal control over their properties and functionalities, making them valuable in various applications such as drug delivery systems, tissue engineering, actuators and soft robotics, and optical sensors and imaging [121][122][123].…”

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

“…These molecules undergo reversible photoisomerization or photodimerization reactions when illuminated with specific wavelengths of light, leading to conformational changes or crosslinking/de-crosslinking of the polymer network [23,122]. Light-responsive polymer-based hydrogels offer precise spatiotemporal control over their properties and functionalities, making them valuable in various applications such as drug delivery systems, tissue engineering, actuators and soft robotics, and optical sensors and imaging [121][122][123]. The choice of photoactive molecules and the design of the hydrogel network can be tailored to achieve the desired light responsiveness, such as specific light wavelengths, intensity, and response kinetics.…”

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

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Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Nguyen

Chien

Cường

2023

Gels

105

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Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physicochemical properties and biocompatibility. Current trends in the development of hydrogel drug delivery systems involve the release of drugs in response to specific triggers such as pH, temperature, or enzymes for targeted drug delivery and to reduce the potential for systemic toxicity. In addition, developing injectable hydrogel formulations that are easily used and sustain drug release during this extended time is a growing interest. Another emerging trend in hydrogel drug delivery is the synthesis of nano hydrogels and other functional substances for improving targeted drug loading and release efficacy. Following these development trends, advanced hydrogels possessing mechanically improved properties, controlled release rates, and biocompatibility is developing as a focus of the field. More complex drug delivery systems such as multi-drug delivery and combination therapies will be developed based on these advancements. In addition, polymer-based hydrogels are gaining increasing attention in personalized medicine because of their ability to be tailored to a specific patient, for example, drug release rates, drug combinations, target-specific drug delivery, improvement of disease treatment effectiveness, and healthcare cost reduction. Overall, hydrogel application is advancing rapidly, towards more efficient and effective drug delivery systems in the future.

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Section: Activation-modulated Drug Delivery Systemmentioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On External ...mentioning

confidence: 99%

See 3 more Smart Citations

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Nguyen

Chien

Cường

2023

Gels

105

View full text Add to dashboard Cite

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The effect of microwave irradiation on the molecular diffusion of the ethyl acetate (EA) into the blend of styrene-butadiene rubber (SBR)/ethylene-propylene-diene monomer rubber (EPDM)

Jourabchi,

Ostad Movahed

2024

Progress in Rubber, Plastics and Recycling Technology

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The rubbers mix to prepare a blend to improve performance and reduce the costs of rubber-made articles. To achieve optimal mechanical and dynamical properties, strong interphases must form between different polymers in a blend. The solvent uptake into the structure of a polymer blend, whether organic or inorganic, is a significant concern in polymer-made articles. In this research, several blends and compounds based on styrene-butadiene rubber (SBR) and ethylene-propylene-diene monomer rubber (EPDM) were prepared. The prepared samples were pre-irradiated by microwaves and immersed in the ethyl acetate (EA) for doing the dynamic swelling experiment. The swelling results were used to determine the molecular diffusion characteristics of the polymer-solvent system. Also, a new method for quantitatively evaluating the interphase between two polymers in a blend was developed using the diffusion characteristics obtained from the swelling experiments. To validate the findings, conventional analytical techniques such as scanning electron microscopy (SEM) and atomic force microscopy (AFM) were employed. The diffusion parameters found in the study were used to determine the degradation mechanism of the immersed SBR/EPDM blend in an organic (EA) solvent and also, to develop a new technique for efficient separation of EA from a solution. In addition, the EPDM/SBR blend with a 20/80 wt ratio at 25°C associated with the lowest interphase showed the highest solvent uptake.

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Preparation of PNIPAM-Azo by RAFT polymerization and their application in thermo- and light-responsive hydrogel

Cited by 2 publications

References 34 publications

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

The effect of microwave irradiation on the molecular diffusion of the ethyl acetate (EA) into the blend of styrene-butadiene rubber (SBR)/ethylene-propylene-diene monomer rubber (EPDM)

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