“…[1,2] Their [1+1]-condensation with hydrazine hydrate or dihydrazides of malonic, glutaric, adipic, [1,2] azelaic, sebacic, 7-oxabicyclo[2.2.1]heptenoic [3] and tartaric [4,5] acids led to macroheterocycles containing one or two ester groups and azine or dihydrazide fragments. One of the synthesized macrolides 4 showed a significant (at the level of erythromycin) antibacterial activity in vitro and in vivo against the museum and field strains of pathogenic microorganisms (Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa).…”