Synthesis of One-Component Nanostructured Polyion Complexes via Polymerization-Induced Electrostatic Self-Assembly

Cai, Meng; Ding, Yi; Wang, Lei; Huang, Lin; Lu, Xinhua; Cai, Yuanli

doi:10.1021/acsmacrolett.8b00005

Cited by 73 publications

(85 citation statements)

References 30 publications

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“…The RAFT‐derived PISA process is based on the chain extension of a soluble macromolecular chain transfer agent (macro‐CTA) with a solvophobic polymer to generate self‐assembled nanoparticles in situ . In addition, different pure and transitional morphologies can easily be obtained by varying the reaction parameters such as the relative lengths of the polymer blocks; composition of the blocks and polymerization solvent; monomer concentration; and other parameters …”

Section: Methodsmentioning

confidence: 99%

Synthesis of Light‐Responsive Pyrene‐Based Polymer Nanoparticles via Polymerization‐Induced Self‐Assembly

Bagheri

Boyer

Lim

2018

Macromol. Rapid Commun.

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The use of an in situ, one-pot polymerization-induced self-assembly method to synthesize light-responsive pyrene-containing nanoparticles is reported. The strategy is based on the chain extension of a hydrophilic macromolecular chain transfer agent, poly(oligo(ethylene glycol) methyl ether methacrylate), using a light-responsive monomer, 1-pyrenemethyl methacrylate (PyMA), via a reversible addition-fragmentation chain transfer dispersion polymerization; yielding nanoparticles of various morphologies (spherical micelles and worm-like micelles). In this process, addition of comonomers, such as butyl methacrylate (BuMA) or methyl methacrylate (MMA), are required to obtain high PyMA monomer conversion (>80% in 24 h). The addition of comonomers reduces the π-π stacking of the pyrene moieties, which facilitates the diffusion of monomers in the nanoparticle core. The addition of BuMA (as a comonomer) offers P(PyMA-co-BuMA) core-forming chains with high mobility that enables the reorganization of chains and then the evolution of morphology to form vesicles. In contrast, when MMA comonomer is used, kinetically trapped spheres are obtained; this is due to the low mobility of the core-forming chains inhibiting in situ morphological evolution. Finally, the UV-light-induced dissociation of these light-responsive nanoparticles due to the gradual cleavage of the pyrene moieties and the subsequent hydrophobic-to-hydrophilic transitions of the core-forming blocks is demonstrated.

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Section: Methodsmentioning

confidence: 99%

Synthesis of Light‐Responsive Pyrene‐Based Polymer Nanoparticles via Polymerization‐Induced Self‐Assembly

Bagheri

Boyer

Lim

2018

Macromol. Rapid Commun.

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“…PIESA stands for polymerization-induced electrostatic self-assembly.Itconsists of synthesizing adouble hydrophilic block copolymer by RAFT in water, with the second block being apolyelectrolyte.T he self-assembly is then induced by in situ polyion complexation, either by the presence of apreformed polyelectrolyte homopolymer during PISA [107,108] and the growth of ap olyelectrolyte block of opposite charge from the macroRAFT agent, or by chain extension of the resulting soluble diblock copolymer with am onomer of opposite charge. [109] Thel ast case leads to the formation of at hird block that strongly interacts upon its growth through electrostatic interactions with the second block, thereby inducing the self-assembly (Figure 4).…”

Section: The Main Parameters At Play For Asuccessful Pisa At Aglancementioning

confidence: 99%

RAFT‐Mediated Polymerization‐Induced Self‐Assembly

2020

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After a brief history that positions polymerization‐induced self‐assembly (PISA) in the field of polymer chemistry, this Review will cover the fundamentals of the PISA mechanism. Furthermore, this Review will also give an overview of some of the features and limitations of RAFT‐mediated PISA in terms of the choice of the components involved, the nature of the nanoobjects that can be obtained and how the syntheses can be controlled, as well as some potential applications.

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“…However, the RAFT‐mediated PISA is typically conducted at high temperatures (e.g., 70 C) by thermal initiation, which is not beneficial for the preparation of temperature sensitive polymer nano‐objects (e.g., protein–polymer conjugate). Recently, photoinitiated PISA (photo‐PISA) developed by our group and others enabled block copolymer nano‐objects to be prepared at room temperature or lower . Temperature‐responsive, CO 2 ‐responsive, protein‐loaded, and protein‐conjugated block copolymer nano‐objects have been prepared by this method.…”

Section: Methodsmentioning

confidence: 99%

Photoinitiated Seeded RAFT Dispersion Polymerization: A Facile Method for the Preparation of Epoxy‐Functionalized Triblock Copolymer Nano‐Objects

Tan

et al. 2018

Macromol. Rapid Commun.

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In this study, a novel photoinitiated seeded reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization is developed for the preparation of epoxy-functionalized triblock copolymer nano-objects at room temperature. Epoxy-functionalized worms and vesicles prepared by photoinitiated RAFT dispersion polymerization of glycidyl methacrylate are used as seeds for chain extension by photoinitiated seeded RAFT dispersion polymerization of methacrylic and acrylic monomers. Good control is maintained during the polymerization with a high polymerization rate. Pure triblock copolymer worms can be prepared by the photoinitiated seeded RAFT dispersion polymerization with a broad degree of polymerization range of the third block. The room temperature feature of photoinitiated seeded RAFT dispersion polymerization is critical to ensure the survival of epoxy moiety after the polymerization. The obtained triblock copolymer nano-objects can be cross-linked by reacting with a diamine. Finally, cross-linked worms are used as the stationary phase of chromatography for selective separation of organic dyes from water.

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Synthesis of One-Component Nanostructured Polyion Complexes via Polymerization-Induced Electrostatic Self-Assembly

Cited by 73 publications

References 30 publications

Synthesis of Light‐Responsive Pyrene‐Based Polymer Nanoparticles via Polymerization‐Induced Self‐Assembly

Synthesis of Light‐Responsive Pyrene‐Based Polymer Nanoparticles via Polymerization‐Induced Self‐Assembly

RAFT‐Mediated Polymerization‐Induced Self‐Assembly

Photoinitiated Seeded RAFT Dispersion Polymerization: A Facile Method for the Preparation of Epoxy‐Functionalized Triblock Copolymer Nano‐Objects

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