Synthesis of Oldenlandia umbellata stabilized silver nanoparticles and their antioxidant effect, antibacterial activity, and bio-compatibility using human lung fibroblast cell line WI-38

Palanisamy, Subramanian; Anjali, Ravichandran; Vinosha, Manoharan; Muthukaruppan, Reka; Somasundaram, Selvakumar; Boomi, Pandi; Anand, Krishnan; Marimuthu, Prabhu Narayanasamy; Somasundaram, Selliah Swamy Nathan; You, SangGuan

doi:10.1016/j.procbio.2019.08.002

Cited by 36 publications

(11 citation statements)

References 45 publications

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“…However, due to the influence of the natural extract (exhibited both as a reaction matrix and as the phytoconstituents coating the nanoparticle), the literature has offered examples regarding the superior antimicrobial effect of larger nanoparticles. For example, in the case of similar silver nanoparticle morphologies (spherical), Subramanian et al [27] recorded a minimum inhibitory concentration (MIC) of 2.5 mg/L (against S. aureus) and 0.5 mg/L (against E. coli) for 22.7 nm NPs, while Dakshayani et al [20] recorded MIC values of 25 mg/L against both lines when using 5-10 nm NPs. The difference in antimicrobial efficiency, assigned to the used extract, could be exploited in future studies that have focused on the most effective plants and extraction procedures for obtaining phytosynthesized NPs with enhanced antimicrobial activity.…”

Section: Recent Findings In the Morphology-properties Correlationmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.Materials 2020, 13, 574 2 of 32 in terms of their toxic potential towards target organisms (leading to their proposal as antimicrobial [4], antiviral [5] or cytogenotoxic agents [6]), their possible negative toxicity has not been thoroughly established. The present review aims to present the advances that have been recorded in the last year in the area of phytosynthesized nanoparticle applications and toxicity studies, as well to underline the shortcomings of the encountered approach. The literature review survey was performed on multiple databases (Scopus, Web of Science, ScienceDirect, SpringerLink, PubMed) and used the main keywords "nanoparticles" and "extract" (as the term "phytosynthesis" was not adopted by all the authors). From the returned results, only the works that were published in the last year (2019) were selected. Furthermore, a supplementary selection was performed by using keywords as "antimicrobial," "cytotoxicity," and "toxicology" (results presented in Figure 1). The results of this preliminary selection led to the return of approximately 1800 unique works (from all the databases). A preliminary validation was manually performed (by reading the keywords and abstract) in order to remove the "false-positive" results. The final validation was performed by reading the entire manuscript. The criteria for inclusion in the present review were: (i) the use of phytosynthesized nanoparticles that were obtained in the laboratory; (ii) the existence of analytical studies for the characterization of the nanoparticles; and (iii) in-depth applications reports. The review is structured in different chapters for each potential application that is related to the toxic effect of the metallic nanoparticles.

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Section: Recent Findings In the Morphology-properties Correlationmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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“…In the case of reducing power assay (FRAP), the antioxidant activity of silver nanoparticles has been also increased on increasing concentration. The best activity was found to be 55 ± 0.95% at 100 μg/ml and as compared to L‐ascorbic acid, silver nanoparticles showed lower antioxidant activity (Subramanian et al, 2019).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Arif

Uddin

2020

Med Devices & Sens

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Green chemistry is the significant field of research as it offers simple, cost-effective, easy, biocompatible and eco-friendly methods for the synthesis of nanomaterials. With the development of nanotechnology, the synthesis of silver nanoparticles (AgNPs) has become important areas of research due to their various applications in industrial, pharmacological and medicinal fields as they exhibited good antibacterial, antifungal, antioxidant, anti-inflammatory, antiviral, anticoagulant, thrombolytic, cytotoxic and photocatalytic properties due to their chemical stability and good biocompatibility.How to cite this article: Arif R, Uddin R. A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications.

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“…These problems necessitated the development of safer, cleaner, and sustainable approach. Recently, producing NPs using different bio‐sources (micro‐bios, plants, diatoms, fungi, actinomycetes, algae) have been achieved, as this method of synthesis of NPs is nontoxic, energy‐efficient, uses cheaper chemicals, eco‐friendly, and can be used in different biological applications (Boomi et al, ; Subramanian et al, ). The plant extracts contain a wide range of green chemicals/phytochemicals including terpenes, phenolic, flavonoids, vitamins, tannins, saponins, alkaloids, and amino acids (Abbasi et al, ; Iqbal et al, ; Iqbal et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Facile green synthesis approach for the production of chromium oxide nanoparticles and their different in vitro biological activities

Iqbal

Abbasi

Munir

et al. 2020

Microscopy Res & Technique

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Green synthesis of nanoparticles using plants has become a promising substitute for the conventional chemical synthesis methods. In the present study, our aim was to synthesize chromium oxide nanoparticles (Cr 2 O 3 NPs) through a facile, low-cost, ecofriendly route using leaf extract of Rhamnus virgata (RV). The formation of Cr 2 O 3 NPs was confirmed and characterized by spectroscopic profile of UV-Vis, EDX, FTIR, and XRD analyses. The UV-visible spectroscopy has confirmed the formation of Cr 2 O 3 NPs by the change of color owing to surface plasmon resonance. The bioactive functional groups present in the leaf extract of RV involved in reduction and stabilization of Cr 2 O 3 NPs were determined by FTIR analysis. Based on XRD analysis, crystalline nature of Cr 2 O 3 NPs was determined. The morphological shape and elemental composition of Cr 2 O 3 NPs were investigated using SEM and EDX analyses, respectively. With growing applications of Cr 2 O 3 NPs in biological perspectives, Cr 2 O 3 NPs were evaluated for diverse biopotentials. Cr 2 O 3 NPs were further investigated for its cytotoxicity potentials against HepG2 and HUH-7 cancer cell lines (IC 50 : 39.66 and 45.87 μg/ml), respectively. Cytotoxicity potential of Cr 2 O 3 NPs was confirmed against promastigotes (IC 50 : 33.24 μg/ml) and amastigotes (IC 50 : 44.31 μg/ml) using Leishmania tropica (KMH 23 ). The Cr 2 O 3 NPs were further evaluated for antioxidants, biostatic, alpha-amylase, and protein kinase inhibition properties. Biocompatibility assay was investigated against human macrophages which confirmed the nontoxic nature of Cr 2 O 3 NPs. Overall, the synthesized Cr 2 O 3 NPs are biocompatible and nontoxic and proved to possess significant biopotentials. In future, different in vivo studies are needed to fully investigate the cytotoxicity and mechanism of action associated with these Cr 2 O 3 NPs. K E Y W O R D S anticancer, antileishmanial, antimicrobial, biocompatibility, Cr 2 O 3 NPs, protein kinase

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Synthesis of Oldenlandia umbellata stabilized silver nanoparticles and their antioxidant effect, antibacterial activity, and bio-compatibility using human lung fibroblast cell line WI-38

Cited by 36 publications

References 45 publications

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Facile green synthesis approach for the production of chromium oxide nanoparticles and their different in vitro biological activities

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