Synthesis of Olaparib derivatives and their antitumor activities

Lou, Xi-yu; Yang, Xuan; Ding, Yi-li; Wang, Jianjun; Yan, Qing-yan; Huang, Xian-gui; Guo, Yang-hui; Wang, Xiang-jing; Xiang, Wensheng

doi:10.1007/s40242-013-2448-5

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…According to the National Comprehensive Cancer Network, single-agent therapy, which includes fluoropyrimidine or gemcitabinebased treatment, and combination therapy regimen, which includes oxaliplatin, cisplatin and capecitabine are the two chemotherapeutic options for GBC patients but both of these are still undergoing clinical trials [13][14][15][16]. The PARP inhibitor olaparib is a novel therapeutic drug that has shown significant improvement in patients with breast cancer and ovarian cancer [17][18][19]. A recent study reported that a GBC patient with a combination of ATM inactivation and STK11 frame-shift mutation showed significant response in inhibiting GBC progression [20].…”

Section: Introductionmentioning

confidence: 99%

An Integrative Systems Biology Approach Identifies Molecular Signatures Associated with Gallbladder Cancer Pathogenesis

Roy

Kshattry

Mandal

et al. 2021

JCM

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Gallbladder cancer (GBC) has a lower incidence rate among the population relative to other cancer types but is a major contributor to the total number of biliary tract system cancer cases. GBC is distinguished from other malignancies by its high mortality, marked geographical variation and poor prognosis. To date no systemic targeted therapy is available for GBC. The main objective of this study is to determine the molecular signatures correlated with GBC development using integrative systems level approaches. We performed analysis of publicly available transcriptomic data to identify differentially regulated genes and pathways. Differential co-expression network analysis and transcriptional regulatory network analysis was performed to identify hub genes and hub transcription factors (TFs) associated with GBC pathogenesis and progression. Subsequently, we assessed the epithelial-mesenchymal transition (EMT) status of the hub genes using a combination of three scoring methods. The identified hub genes including, CDC6, MAPK15, CCNB2, BIRC7, L3MBTL1 were found to be regulators of cell cycle components which suggested their potential role in GBC pathogenesis and progression.

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Section: Introductionmentioning

confidence: 99%

An Integrative Systems Biology Approach Identifies Molecular Signatures Associated with Gallbladder Cancer Pathogenesis

Roy

Kshattry

Mandal

et al. 2021

JCM

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“…Based on the above enlightenment, we aimed at the synthesis of POPs via the DA reaction between furan groups and alkynyl groups (DA-POPs). This reaction is widely used in the synthesis of natural molecules, but it has not been used to prepare POPs. Compared with the cycloolefin, terminal alkynyls have less steric hindrance, which may be conducive to the occurrence of polymerization reaction .…”

mentioning

confidence: 99%

Porous Organic Polymers via Diels–Alder Reaction for the Removal of Cr(VI) from Aqueous Solutions

et al. 2022

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The Diels–Alder reaction is striking as a prominent synthetic tool for the rapid construction of complex molecular frameworks, but the synthesis of porous organic polymers (POPs) via the Diels–Alder reaction is rare. Herein, we report the solvothermal synthesis of a new type of POPs (DA-POPs) via the furan/alkynyl Diels–Alder reaction. These polymers show favorable porous properties and high specific surface areas (up to 1041 m2·g–1). Meanwhile, the high porosity in conjuction of ether bridges in the DA-POPs enable a fine adsorption performance for the removal of Cr(VI) from aqueous solutions.

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