Synthesis of Novel Triazole‐incorporated Isatin Derivatives as Antifungal, Antitubercular, and Antioxidant Agents and Molecular Docking Study

Shaikh, Mubarak H.; Subhedar, Dnyaneshwar D.; Khan, Firoz A. Kalam; Sangshetti, Jaiprakash N.; Nawale, Laxman; Arkile, Manisha; Sarkar, Dhiman; Shingate, Bapurao B.

doi:10.1002/jhet.2598

Cited by 47 publications

(22 citation statements)

References 31 publications

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“…Compounds with a piperazine moiety (109a-c) displayed the biggest antifungal inhibition activity (Figure 49). Shaikh et al [115] described novel triazole-based isatin derivatives that were evaluated for biological activity using click chemistry. e 1,2,3-triazole-based isatin compounds showed good-to-moderate activity against all five human pathogenic fungal strains tested.…”

Section: -Mercaptobenzimidazolementioning

confidence: 99%

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

Marzi

Farjam

Kazeminejad

et al. 2022

Journal of Chemistry

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A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology.

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Section: -Mercaptobenzimidazolementioning

confidence: 99%

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

Marzi

Farjam

Kazeminejad

et al. 2022

Journal of Chemistry

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“…Sriram et al designed, synthesized six 1, 2, 3-triazole-p-aminosalicylic acid-isatin hybrides and screened for their in vitro anti-TB activities against MTB H37Rv by Abdu-Allah et al [39,40]. Three of them 6a, 6d, 6e exhibited promising activities with MIC of 0.39-12.5 μg/ml, suggesting their potential as anti-TB agents while the rest three (MIC: > 25 μg/ml) were inactive (▶Fig.…”

Section: Antitubercular Activitiesmentioning

confidence: 99%

Recent Advancement of Synthesis of Isatins as a Versatile Pharmacophore: A review

Kumar¹,

Singh

Kumar

2020

Drug Res (Stuttg)

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Isatin (1 H-indole-2, 3-Dione) and its derivatives are versatile compounds which acts as a precursor for a large number of pharmacologically active compounds. Therefore isatins have a significant importance in the synthesis of different heterocyclic compounds. Isatins show variety of biological activities. In this review we focus on synthetic methods of isatins and their biological activities such as antimicrobial, anticonvulsant, anti-inflammatory and analgesic activity, antitubercular activity.

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“…A new class of 1,2,3‐triazole‐isatin hybrids 3 were tested for their in vitro anti‐TB activities against MTB H37Ra by Shingate et al . A significant number of hybrids showed potential anti‐TB activities with IC 50 in a range of 7.56 to 29.05 μg/mL, and were far less active than the references RIF and INH (IC 50 : 0.043 and 0.075 μg/mL).…”

Section: Isatin‐azole Hybridsmentioning

confidence: 99%

Isatin Derivatives with Potential Antitubercular Activities

Jiang

Wang

Liu

et al. 2018

Journal of Heterocyclic Chem

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Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the lungs but can spread to other vital organs. The re‐emergence and wide spread of new virulent forms of Mycobacterium tuberculosis that are resistant to some or all first and second line antitubercular agents has reached an alarming level in recent decades. Thus, it is imperative to develop more effective agents. Isatin derivatives are endowed with diverse biological properties, therefore thousands of isatin derivatives have been synthesized in hopes of discovering new candidates with potential antitubercular activities against both drug‐susceptible and drug‐resistant strains. This review summarizes the recent developments of isatin derivatives with potential antitubercular activities.

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Synthesis of Novel Triazole‐incorporated Isatin Derivatives as Antifungal, Antitubercular, and Antioxidant Agents and Molecular Docking Study

Abstract: A library of 1,2,3‐triazoles efficiently prepared via click chemistry and evaluated for their antifungal, antitubercular, antioxidant, cytotoxicity, molecular docking and ADME prediction.

Cited by 47 publications

References 31 publications

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

Recent Advancement of Synthesis of Isatins as a Versatile Pharmacophore: A review

Isatin Derivatives with Potential Antitubercular Activities

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