Synthesis of novel hybrid hetero-steroids: Molecular docking study augmented anti-proliferative properties against cancerous cells

Mohamed, Sherif A.; El-kady, Dina S.; Abdrabou, Ahmed; Tantawy, Mohamed A.; Abdelhalim, Mervat M.; Elazabawy, Samia R.; Abdallah, Amira E. M.; Elmegeed, Gamal A.

doi:10.1016/j.steroids.2019.108527

Cited by 12 publications

(1 citation statement)

References 21 publications

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“…[57] Out of the nine compounds Steroids with a heterogeneous moiety including nitrogen or sulfur may have increased biological activity due to their low toxicity, decreased multi-drug resistance (MDR), and high bioavailability as a result of their ability to penetrate cell walls. [58] The novel hetero-steroid derivatives 13 a-e (Figure 4) were evaluated for cytotoxicity against lung and hepatocellular carcinoma cells by Mohamed et al [59] Compounds 13 a and 13 b were found to have the lowest IC 50 values and the most cytotoxic effects on all examined cell lines. Compound 13 a displayed the lowest IC 50 in the case of the A549 cell (21.98 μl/ ml).…”

Section: Anticancermentioning

confidence: 99%

Pharmacological Perspectives of 2‐alkoxy‐3‐Cyanopyridine Scaffolds: An Up‐to‐Date Review

Mahesha,

Shetty

2024

ChemistrySelect

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The 2‐alkoxy‐3‐cyanopyridine derivatives’ straightforward synthesis, ease of structural manipulation, and variety of intriguing biological activity continue to captivate medicinal chemists. A substantial body of research has demonstrated that these derivatives exhibit several intriguing biological characteristics, including anticancer, antibacterial, antidiabetic, antioxidant, vasorelaxant, antiviral, and anti‐inflammatory effects. Based on the basic skeleton of 2‐alkoxy‐3‐cyanopyridine, some lead compounds have been prepared with varied pharmaceutical characteristics. These served as excellent models for the development of novel medications since they showed potential in vitro and in vivo action against several cell lines that were both drug‐susceptible and drug‐resistant. To expand the use of 2‐alkoxy‐3‐cyanopyridine in biomedicine, though, a lot more efforts are essential. To combat medication resistance and boost specificity, potential hybrids that unite the 2‐alkoxy‐3‐cyanopyridine moiety with other pharmacophores are indeed required. This review offers a summary of pharmacological screening, including studies of pertinent structure‐activity connections, action mechanisms, and potential therapeutic use.

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Section: Anticancermentioning

confidence: 99%