Synthesis of Novel Galactopyranosyl‐Derived Spiro Barbiturates.

Abstract

Carbohydrates U 0500Synthesis of Novel Galactopyranosyl-Derived Spiro Barbiturates. -Eleven title compounds of type (VI) are prepared and found to possess antibacterial and antifungal activities. -(INGLE*, V. N.; GAIDHANE, P. K.; DUTTA, S. S.; NAHA, P. P.; SENGUPTA, M. S.; J. Carbohydr. Chem. 25 (2006) 7-9, 661-671; Dep. Chem., Nagpur Univ., Nagpur 440 010, India; Eng.) -M. Bohle 21-167

Pyrimidine-2,4,6-trione Derivatives and Their Inhibition of Mutant SOD1-Dependent Protein Aggregation. Toward a Treatment for Amyotrophic Lateral Sclerosis

“…16 After the solvent was removed under vacuum, without any further purification, the crude urea compounds were treated with malonic acid in acetic acid/acetic anhydride at 60–90 °C to provide PYT compounds in moderate to high yields. 17 Most of the final products were easily recrystallized from ether/hexanes. The reactions were carried out in 20 mL vials over a period of two days, and often 8–12 reactions were set up at the same time on pie blocks with an IKA stir plate.…”

“…As shown in Scheme , starting from commercially available S , S -dimethyl carbonodithioate and amines, urea intermediates were synthesized in high yields . After the solvent was removed under vacuum, without any further purification, the crude urea compounds were treated with malonic acid in acetic acid/acetic anhydride at 60−90 °C to provide PYT compounds in moderate to high yields . Most of the final products were easily recrystallized from ether/hexanes.…”