Synthesis of Novel Galactopyranosyl‐Derived Spiro Barbiturates

Design and synthesis of 1,3-diphenylpyrimidine-2,4(1H,3H)-dione derivatives as antitumor agents via elevating ROS production to induce apoptosis

“…The 1,3-di-subsitituedphenyl-pyrimidine-2,4,6(1 H ,3 H ,5 H )-trione intermediates 4a–4g , 40 the 6-chloro-1,3-di-substituted phenyl-pyrimidine-2,4(1 H ,3 H )-trione intermediates 5a–5g , 41 and 6-(aminos)-1,3-di-substituted phenyl-pyrimidine-2,4(1 H ,3 H )-dione 6a–6b , 6d–6e or 6g–6m 42 were obtained according to related reported procedures.…”

Enantioselective Catalytic Transformations of Barbituric Acid Derivatives

“…Phenobarbital, involved in the treatment of certain types of epilepsy, derived from the original barbital but displays two different substituents at C-5 position (Figure 1a) [7]. The opportunity afforded by the double functionalization of the C-5 position of barbituric acid allowed the construction of several spiro-compounds and, thus, more rigid architectures highlighted by the development of nucleotide mimics [8], inhibitor of matrix metalloproteinases (MMP) [9] and anticancer agents [10], for example ( Figure 1b-d) [11,12]. On the other hand, the synthesis of fused-bicycle derivatives led to ingredients possessing either The versatile properties of products obtained from barbituric acid elicited the motivation of organic chemists to explore its chemistry [3,4,6], and more recent evolutions have met the development of efficient multicomponent reactions (MCR) [16,18].…”

Regiospecific synthesis of novel spiro‐pyrimidobarbiturates with promising antibacterial activities

“…Moreover, some spiro-barbiturate derivatives have a wide range of biological impacts such as spiro-cyclohexanone barbiturates I as α-glucosidase inhibitors [15], spiro-pyrazolobarbiturate J as hypnotic activity [16], spiro-tetrahydrofuran barbiturates K have antitumor activity [17], spiro-dihydrofuran barbiturates L have promising anticonvulsants, anti-AIDS agents and anti-inflammatory remedies [18], and spirogalactopyranosyl barbiturates M have both antibacterial and antifungal activities [19] (Figure 2).…”