Synthesis of Novel Derivatives of (Benz)Imidazo[2,1-b]Pyrimido[4,5-d][1,3]Thiazine

Abstract

Several derivatives of the novel heterocyclic systems 2-substituted-imidazo- and benzimidazo-[2,1- b]pyrimido[4,5- d][1,3]thiazine have been synthesised through the one-pot cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with imidazolidine-2-thione and 1 H-benzimidazole-2(3 H)-thione and subsequently substituted by various secondary amines in moderately good yields.