Synthesis of novel bis- and poly(hydrazinylthiazole) linked to benzofuran or benzothiazole as new hybrid molecules

Abstract

A novel series of bis-and poly(thiazoles) substituted with benzofuran and benzothiazole moieties were prepared in good yields by the reaction of the appropriate bis(α-bromoketones) with the corresponding bisand poly(hydrazinecarbothioamide) in refluxing EtOH in the presence of TEA. The structures of the new compounds were confirmed based on elemental analyses as well as spectral data.

Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

“…It is worth noting that bis-thiosemicarbazones 9a-c were prepared via the condensation of acetophenones 12a and 12b or bis-aldehydes 12c with thiosemicarbazide 13 ( Scheme 4 ) [ [73] , [74] , [75] ].

Scheme 4 Synthesis of bis-thiosemicarbazones 9a-c .

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Recent insights into antibacterial potential of benzothiazole derivatives

“…Ethoxzolamide, benzothiazol-2-ylthiomethyl thiocynate (TCMTB) and dimazole are the clinically approved antimicrobial drugs having benzothiazole moiety (Fig. 1) [27,28].…”

One-pot, simple, and facile synthesis of 4-(3-benzylbenzo[d]thiazol-2(3H)-ylidene)-cyclohexa-2,5-dien-1-one derivatives via a novel three-component reaction

“…5,6 Benzothiazoles and their analogues are important building blocks and synthetic intermediates in the synthesis of new drugs, pesticides, and dyes, and are utilized in medicinal chemistry. 7,8 Derivatives of benzothiazole have been reported to show a wide spectrum of pharmacological activities and agrochemical applications like anti-convulsant, 9 antiallergy, 10 antifungal, 10 anti-microbial, 11 anti-oxidant, 12 anti-inflammatory, 12 anti-diabetic, 13 neuroprotective, and many others 14 (Figure 1). On the other hand, benzothiazoles are also widely used in a variety of consumer and industrial products such as nonlinear optics (NLOs), organic light-emitting diodes (OLEDs), fluorescent probes, luminescence, chemosensors, 15–17 and liquid crystals.…”