“…However, selected structural modifications of acetaminophen with the benzothiazole ring have afforded pharmacologically active compounds with decreased nephrotoxicity as compared to the parent molecule, i.e., acetaminophen [29]. On the other hand, the antibacterial potential of benzothiazoles is undeniable, as an important number of recent reports have described their efficacy against pathogenic microbes via numerous mechanisms of action, such as the inhibition of reactive chemical species [30], inhibition of uridine diphosphate-n-acetyl enol pyruvyl glucosamine reductase [31], DNA gyrase inhibition [32,33], peptide deformylase inhibition [34], aldose reductase inhibition [35], dihydroorotase inhibition [36], casdihydrofolate reductase inhibition [37], enoyl acyl carrier protein reductase inhibition [38], dialkylglycine decarboxylase inhibition [39], dehydrosqualene synthase inhibition [40], DNA gyrase and tyrosine kinase inhibition [41] and dihydropteroate synthase inhibition [42] among others [43].…”