Synthesis of Novel Azo Schiff Bases and Their Antibacterial and Antifungal Activities

Abstract

Abstract:Ten new azo Schiff bases 5a-h and 7a-b were prepared in excellent yields via the condensation of different aromatic amines and a new azoaldehyde, 2-hydroxy-3-methoxy-5-(4-methoxyphenylazo)benzaldehyde (4) by two different methods. All new compounds were tested against five microorganisms: Staphylococcus aureus (Gram positive and methicillin resistant), Bacillus subtilis (Gram positive), Kelebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli (all Gram negative). Compounds 4, 5a, 5c, 5d and 5g were moderately active against Staphylococcus aureus and Bacillus subtilis. Compound 7b was highly active against Bacillus subtilis and moderately active against Staphylococcus aureus. Other compounds were inactive against these strains of bacteria. The antifungal activities of these compounds were also tested against eight different fungal species. None of them were active against the fungi species tested.

Synthesis, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases Based on 1,3-Docarbonyl Phenyl Dihydrazide, 1,4-Docarbonyl Phenyl Dihydrazide

“…During the last two or three decades, attention has been increasingly paid to the synthesis of macrocyclic hydrazone (VI, VII, VIII), which exhibits various biological activities including antibacterial, fungicidal, tuberculostatic and plant growth regulative properties [39]. It was judicious to investigate the synthesis of various new types of Schiff base and studied their antibacterial activity against four strains of bacteria (Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Salmonella typhi).…”

Transition Metal Complexes with Antipyrine‐Derived Schiff Bases: Synthesis and Antibacterial Activity

“…Schiff bases are important precursors for the synthesis of some bioactive compounds [4,5]. Schiff bases have received considerable attention since the discovery of their antibacterial [6,7], antifungal [8], anti-HIV [9,10], anti-inflammatory [11], anticonvulsant [12,13], antiviral [14], and anticancer properties [15][16][17]. The presence of the inimical grouping in these organic ligands plays an important part in manifesting these biological characteristics [18][19][20].…”

Synthesis, spectroscopic characterization and antibacterial activities of three Schiff bases derived from dehydroacetic acid with various substituted anilines

“…Schiff bases have been reported to be potential anticancer drugs [4]. The azomethine linkage of the Schiff bases is responsible for various antibacterial, antifungal, herbicidal, clinical and analytical activities [5,6]. Schiff base ligands that contain strong donor sites like phenoxo oxygen atoms and imine nitrogen atoms are brilliant for analytical and biological applications [7,8].…”