Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe₃O₄ Magnetic Nanoparticles and Study of Their Antioxidant Activity

Abstract

The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe 3 O 4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure-activity relationships for splitting antioxidant and cytotoxic activity of these compounds.

Microwave assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities

“…The underlying idea for the use of microwave dielectric heating in organic synthesis is that commercial laboratory apparatus favored significant rate enhancements compared to reactions, which run with conventional heating, (i.e. in oil bath) 15 and higher product yields.…”

Antioxidant Potential of Pyrimidine Derivatives against Oxidative Stress

“…Khoobi et al [45] synthesized novel series of 4H-chromenes containing a pyrimidine-2-thione. The antioxidant activities of the synthesized chromenopyrimidinethiones were evaluated by two in vitro methods (DPPH and ABTS) in order to compare the results.…”

“…3a) exhibited the most potent antioxidant activity in both DPPH and ABTS methods. Although compounds 2a was not as potent as reference drug Trolox, but its antioxidant activity could be considered as associated property of the title compound [45] .…”

Synthesis process, magnetic and electronic properties of ferrite nanoparticle MnFe2O4

“…The ferrite and magnetite nanoparticles were prepared and characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction (XRD), vibrating sample magnetometer, scanning electron microscopy and transmission electron microscopy (Khoobi, Motevalizadeh, Asadgol, Forootanfar, Shafie and Faramarzi, 2015; Dalvand et al , 2016; Motevalizadeh et al , 2015; Khoobi, Delshad, Vosooghi, Alipour, Hamadi, Alipour, Hamedani, Sadat Ebrahimi, Safaei, Foroumadi, Shafiee, 2015; Tarasi, Khoobi, Niknejad, Ramazani, Mamani, Bahadorikhalili and Shafiee, 2016; Dayyani et al , 2015; Fardood, Atrak and Ramazani, 2017; Fardood, Ramazani and Moradi, 2017; Sadri et al , 2016; Khoobi et al , 2014; Tarasi, Ramazani, Ghorbanloo, Khoobi, Aghahosseini, Joo and Shafiee, 2016; Ramazania et al , 2015; baSadri et al , 2014; Sadri et al , 2014). Magnetic drug targeting is a drug delivery strategy that can be used to improve the therapeutic efficiency on tumor cells and reduce the side effects on normal cells and tissues (Sadri et al , 2015).…”