Synthesis of novel 3,4‐diaryl‐1H‐pyrroles

Abstract

The synthesis of a series of novel 3,4‐diaryl‐1H‐pyrroles and related arylalkenes from p‐bromo thiophenol, tosylmethyl isocyanide and commercially available materials is reported. Arylalkenes having electron‐withdrawing substituents gave higher yield of 3,4‐diaryl‐1H‐pyrroles.

Natural phosphate as an efficient and green catalyst for synthesis of tetraketone and xanthene derivatives

“…They have exhibited antibacterial, antiviral, anti-inflammatory [10,11] and biological [12,13] properties, in addition to their applications in material science. Apart from quantum dots, which are known as inorganic fluorophores [14][15][16], xanthene-based compounds as organic fluorophores are commonly used in applications due to their brightness, high quantum yields, and low-energy excitation.…”

One‐pot multicomponent synthesis of novel 2‐(piperazin‐1‐yl) quinoxaline and benzimidazole derivatives, using a novel sulfamic acid functionalized Fe3O4 MNPs as highly effective nanocatalyst

“…N-heterocyclic compounds are some of the most versatile building blocks in medicinal chemistry that are utilized in the most active bioorganic compounds. [1,2] Among these, quinoxaline (benzopyrazine) derivatives, especially 2-amino quinoxalines as well as benzimidazole moiety, play a vital role in the development of biological compounds with valuable activities, including antiviral, antibacterial, antimicrobial, antifungal, antimalarial, antidepressant, antidiabetic and kinase (c-Met) inhibitory, and anticancer effects. [3][4][5] In addition, quinoxaline as a bioisostere of different heterocyclic systems such as benzimidazole, pteridine, quinazoline, quinoline, benzothiophene, pyridine, and pyrazine has become a significant portion of various bioactive small molecules in the pharmaceutical field.…”

“…N‐heterocyclic compounds are some of the most versatile building blocks in medicinal chemistry that are utilized in the most active bioorganic compounds. [ 1,2 ] Among these, quinoxaline (benzopyrazine) derivatives, especially 2‐amino quinoxalines as well as benzimidazole moiety, play a vital role in the development of biological compounds with valuable activities, including antiviral, antibacterial, antimicrobial, antifungal, antimalarial, antidepressant, antidiabetic and kinase (c‐Met) inhibitory, and anticancer effects. [ 3–5 ]…”

Convenient syntheses of 5‐[(2‐methyl‐5‐nitro‐1H‐imidazol‐1‐yl)methyl]‐1,3,4‐oxadiazole‐2(3H)thione and N‐substituted 2‐amino‐5‐[(2‐methyl‐5‐nitro‐1H‐imidazol‐1‐yl)methyl]‐1,3,4‐thiadiazoles

“…Besides, synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives have a great deal of importance because of their broad spectrums of biological characteristics such as anti-inflammatory, anti-fungal and anti-bacterial activities [6][7][8][9][10][11][12][13]. As an extension of our previous work on the synthesis of small bioactive heterocyclic molecules [14][15][16][17], we wish to report the synthesis of 5-[(2-methyl-5-nitro-1H-imidazole-1-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione (10) and its methyl and ethyl thioacetate derivatives 11a-b, and N-substituted 2-amino-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-thiadiazoles (13a-f) as possible effective antimicrobial drugs. …”