Synthesis of novel 3-(1,2,4-oxadiazol-5-yl)thiophen-2-amine derivatives via gewald reaction

Abstract

Novel substituted 3-(1,2,4-oxadiazol-5-yl)thiophen-2-amines were obtained by the multicomponent Gewald reaction of an activated nitrile with 1,2,4-oxadiazole moiety, a carbonyl component and elemental sulphur in the presence of morpholine as a catalyst.