Synthesis of New VO(II), Co(II), Ni(II) and Cu(II) Complexes with Isatin-3-Chloro-4-Floroaniline and 2-Pyridinecarboxylidene-4-Aminoantipyrine and their Antimicrobial Studies

Abstract

The complexes of tailor made ligands with life essential metal ions may be an emerging area to answer the problems of multi drug resistance. The coordination complexes of VO(II), Co(II), Ni(II) and Cu(II) with the Schiff bases derived from isatin with 3-chloro-4-floroaniline and 2-pyridinecarboxaldehyde with 4-aminoantipyrine have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, molar conductance, electronic spectra, FT-IR, FAB mass and magnetic susceptibility measurements. FAB mass data show degradation of complexes. Both the ligands behave as bidentate and tridentate coordinating through O and N donor. The complexes exhibit coordination number 4, 5 or 6. The Schiff base and metal complexes show a good activity against the bacteria; Staphylococcus aureus, Escherichia coli and Streptococcus fecalis and fungi Aspergillus niger, Trichoderma polysporum, Candida albicans and Aspergillus flavus. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases. The minimum inhibitory concentrations of the metal complexes were found in the range 10~40 µg/mL.

Synthesis, Characterization, and Antimicrobial Studies of N, ODonor Schiff Base Polymeric Complexes

“…The development of the field of bioinorganic chemistry has increased the interest in Schiff base complexes, since it has been recognized that many of these complexes may serve as models for biologically important species. Schiff base metal complexes were investigated for fungicidal, fungistatic, bactericidal, and bacteriostatic activities [12][13][14][15].…”

Microwave Preparation, Spectral Studies and Antimicrobial Activities Evaluation of Mn(II),Ni(II), Hg(II),Co(II) and Cu(II) Complexes with Schiff Base Ligand

“…The two bands at (1678, 1620) cm -1 attributed to the two azomethine groups of the ligand, after complexation, these bands were shifted to lower frequencies in the region (1668-1661) cm -1 and (1617-1614) cm -1 , elucidating the bonding of nitrogen atoms of (C=N) imine groups to the metal ions. This can be illustrated by the granting of electrons from nitrogen to the vacuous d-orbital of the metal atom [8]. The phenolic C-O stretching vibration that showed at (1211) cm -1 in the ligand, this band was shifted towards higher frequencies about (22-16) cm -1 in the complexes, Figure (2).…”

“…In every day of life, the improved pharmaceuticals in coordination chemistry have a large interdisciplinary relation for transition metal ion that are used to control the harmful effects of fungi and bacteria [1][2][3][4][5][6][7][8]. The studies about behavior ligands in the chelation with transition metal ions by using the microwave as assisted were considered as one of the important properties in green chemistry [9].…”

Synthesis and in silico investigation of Schiff base derivatives of 1H-indole-2,3-diones and their Co(II) and Ni(II) complexes as antimicrobial agents

“…Most drugs are administered orally for two major reasons: its convenience to patients and ease of manufacturing oral drugs. Therapeutic agents administered orally have to be adequately available in systemic circulation (orally bioavailable) in order to reach their target receptor/proteins (Mishra et al, 2012;Aungst, 2017). Lipinski proposed a rule, known as 'rule of five' (ro5) used to assess drug-likeness of potential drug molecules.…”

“…In principle, the polarity of each metal ion on coordination with the ligands reduces due to its overlap with the ligand orbital and partial sharing of the positive charge of the metal ion with the donor groups within the chelate ring system (Hassan, 1991;Raman et al, 2007;. Moreover, chelation increases the delocalization of electrons over the whole chelate rings (Ibezim et al, 2015) leading to increase in the lipophilic nature of the central metal atom which in turn favours the permeation of the complexes through the lipid membranes while blocking the metal binding sites of the microbial enzymes and increasing the activity of the complexes Mishra et al, 2012). These complexes interfere with microbial cellular respiration and block the synthesis of proteins which further inhibit the growth of the microorganisms (Raman et al, 2007).…”