Synthesis of new triazole linked carbohybrids with ROS-mediated toxicity in breast cancer

Abstract

Carbohybrids are an important class of molecules which exhibit diverse biological activities. New coumarins and quinolones linked carbohybrids are synthesised which are showing selective anticancer activity.

Application of triazoles in the structural modification of natural products

“…As noted earlier, derivatives of coumarin-triazole 15 exhibit anti-breast cancer activity 58 . Kraljevic et al.…”

“…The anticancer activity of the newly synthesised triazole-linked N -glycosides of coumarins and quinolones was determined by Kumari et al. 58 Compound 6 ( Figure 4 ) displayed low micromolar (IC 50 = 10.97 µM) and selective toxicity against MCF-7, a breast cancer cell line. Further study revealed that the anticancer activity of the active compound was due to the formation of reactive oxygen species (ROS) however without significant nuclear DNA damage.…”

“…Coumarin-triazole derivatives not only possess anti-breast cancer activity 58 but also exhibit anti-liver cancer activity 68 and anti-pancreatic cancer activity 70 . Farley et al.…”

“…Coumarin-triazole derivatives not only exhibit anti-breast cancer activity 58 , anti-liver cancer activity 68 , and anti-pancreatic cancer activity 70 , but also they possess activity against multiple types of cancer cells. A series of coumarin-based target-specific probes for cancer theranostic applications that played a dual role in the field of both diagnosis and therapy was screened for anticancer activity against breast cancer (MCF7) and human epitheloid cervix carcinoma (HeLa) cell lines 90 .…”

“…Coumarin-triazole derivatives not only possess anticancer activity 58 , 68 , 70 , 90–93 , but also they exhibit anti-inflammatory activity 115 . Lipeeva et al.…”