Synthesis of new series of 4, 5-dihydroisoxazole-5-carboxylate derivatives for the study of their liquid crystalline properties

Abstract

A new series of 4,5-dihydroisoxazole-5-carboxylate derivatives were synthesized via [3+2] cycloaddition reaction between ethyl acrylate and nitrile oxide generated in situ in presence of Chloramine-T. The synthesized derivatives were characterized by Mass, IR and NMR Spectroscopy and their mesomorphic behavior were studied using DSC and Polarising Optical Microscopy.

Potassium iodate ($$\hbox {KIO}_{3}$$) as a novel reagent for the synthesis of isoxazolines: evaluation of antimicrobial activity of the products

“…Alkylated benzaldehydes (1 mmol) and aldoximes (1 mmol) were prepared by reported methods. 6 In a typical procedure, p-propoxy-benzaldoxime and allyl bromide were made to react with KIO 3 (1.2 mmol) for the generation of nitrile oxide in situ under reflux conditions for 4-6 h in the presence of acetic acid in catalytic amount and ethanol as solvent. The completion of the reaction was monitored by TLC.…”

“…They are also found to possess mesogenic core exhibiting liquid crystalline properties. 5,6 These varied applications have attracted more interest in isoxazolines and their synthetic routes. Various methods have been reported in the literature.…”