A novel reagent for the synthesis of isoxazolines has been reported. Aryl aldoximes were made to react with alkenes in the presence of KIO 3 as the oxidising agent. This new reagent has been useful as an oxidant in the synthesis of isoxazoline and its function is attributed to the generation of nitrile oxide, which is an important intermediate for the synthesis of the valuable heterocycle like isoxazoline.
Introduction and Aim: Biosynthesis of metal nanoparticles is an important branch of nanobiotechnology. In recent years, microbial biosynthesis of nanoparticles is gaining importance due to its simplicity and eco-friendliness.
Materials and Methods: In this study, Selenium nanoparticles (Se NPs) were synthesized by using the fungi Fusarium sp. isolated from agricultural soil. Mycosynthesized Se NPs were characterized by UV-Vis spectrometer and Dynamic Light Scattering (DLS) analysis. Further biosynthesized Se NPs screened for different biological activities such as antibacterial, antioxidant, hemolysis, cytotoxicity and catalytic activity.
Results: Synthesis Se NPs was preliminary observed by a color change from pale yellow to orange red color and confirmed by UV peak at 342 nm. The DLS result shows the particles size ranges from 19 to 43 nm.The obtained result showed that the synthesized Se NPs possess good antibacterial activity against human pathogens such as E. coli, Staphylococcus aureus, Salmonella typhi and Klebsiella pneumonia. Further biogenic Se NPs showed less cytotoxicity on yeast cells and slight hemolysis.
Conclusion: The synthesized Se NPs have good antioxidant property and antibacterial activity with less haemolytic property these properties lead to use of Se NPs in different biomedical applications. This Se NPs Also showed an efficient catalytic activity by degrading hazardous dyes such as methylene blue and bromothymol blue.
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