Synthesis of New Series of 4,5-Dihydroisoxazole-5-carbonitrile Derivatives for the Study of their Liquid Crystalline Properties

Kotian, Sumana Y.; N, Narayana U. Kudva; Byrappa, K.; Lokanatha, K. M.

doi:10.1016/j.matpr.2016.11.077

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Some of ∆ 2 -isoxazolines exhibit inhibitory activity in tubulin polymerization [ 3 ] and anticancer activity against human prostate cancer cell lines [ 4 ]. The liquid crystalline properties of ∆ 2 -isoxazolines are also known [ 5 ]. The synthetic potential of the use of ∆ 2 -isoxazolines was explored in syntheses of β -hydroxyketones, γ -aminoalcohols, α , β -unsaturated oximes, and β -hydroxynitriles [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Regiospecific formation of the nitromethyl-substituted 3-phenyl-4,5-dihydroisoxazole via [3 + 2] cycloaddition

et al. 2018

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Abstract5-(Nitromethyl)-3-phenyl-4,5-dihydroisoxazole was obtained as a product of a high-yielding [3 + 2] cycloaddition reaction of in situ-generated benzonitrile N-oxide and 3-nitroprop-1-ene. For the first time, the regiochemistry of this reaction was unambiguously proven by X-ray structural analysis. The quantum-chemical calculation performed at the M06-2X/6-31G(d) (PCM) theoretical level affords a basis for explaining the course of reaction as well as the nature of transition states. Next, further DFT calculations together with spectral data shed light on structural aspects of the product.Graphical abstract Electronic supplementary materialThe online version of this article (10.1007/s00706-018-2227-6) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Regiospecific formation of the nitromethyl-substituted 3-phenyl-4,5-dihydroisoxazole via [3 + 2] cycloaddition

et al. 2018

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Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review

Nayak

Gaonkar

Harshitha

2022

Journal of Saudi Chemical Society

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Chloramine-T in Organic Synthesis and Analysis of Organic Functional Groups: A Review

et al. 2021

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The diverse nature of Chloramine-T, the sodium salt of N-chloro-p-toluenesulfonamide, abbreviated as CAT, acts as a source of halonium cation and nitrogen anion, and acts as both base and nucleophile. It reacts with broad range of functional groups and brings divergent molecular transformations to synthetic chemistry. CAT has also gained much recognition as a mild oxidant for several organic moieties and has been used as a versatile reagent for the estimation of various functional groups in analytical chemistry. This review relays the synthetic and analytic utility of CAT from different literature sources. As aspects of the synthetic utility of CAT have not previously been reviewed, this article gives a comprehensive profile of the CAT reagent for further research development.

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Synthesis of New Series of 4,5-Dihydroisoxazole-5-carbonitrile Derivatives for the Study of their Liquid Crystalline Properties

Cited by 3 publications

References 6 publications

Regiospecific formation of the nitromethyl-substituted 3-phenyl-4,5-dihydroisoxazole via [3 + 2] cycloaddition

Regiospecific formation of the nitromethyl-substituted 3-phenyl-4,5-dihydroisoxazole via [3 + 2] cycloaddition

Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry: An up to date review

Chloramine-T in Organic Synthesis and Analysis of Organic Functional Groups: A Review

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