Abstract:Background:
In the present study, new triazine derivatives 3, 4, 5, 6, 8 and 10 were
synthesized starting from readily available cyanuric chloride 1 via nucleophilic displacement with
morpholine followed by Suzuki or Stille coupling reactions and then the thermal displacement of
chlorine atom with diverse substituted amines.
Methods:
All synthesized compounds were screened for their cytotoxic activity against HT-29,
MDA-MB-231, and HEK293 cell lines.
Results and Conclusion:
Compounds 6a (IC50 (µM): 0.32 fo… Show more
In the present study, a new water-soluble proton transfer cytotoxic compound (dpp)(dapt).H2O (Dx) (where dpp = diphenylphosphinate and dapt = 2,6-diamino-4-phenyl-1,3,5-triazin-1-ium ) was synthesized and characterized by IR and NMR...
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