Synthesis of new derivatives of 5,6,7,8-tetrahydro-1,6-naphthyridines and their pharmacological properties

Domino synthesis of functionalized 1,6-naphthyridines and their in vitro anti-inflammatory and anti-oxidant efficacies

“…2,3 These pyridine structures are the most significant because of their wide spectrum of promising biological activities such as anticonvulsants, 4 anti-inflammatory, 5 antimitotic, 6 agents antioxidant, 7,8 anticancer, 9,10 and antimicrobial activities. 11 Similarly, 1,6-naphthyridines [12][13][14][15][16][17] have established significant attention due to their broad range of bioactivities [18][19][20][21][22][23][24] such as antimicrobial, 25 anti-analgesic, 26 antifungal, 27,28 anticancer, [29][30][31] antioxidant, 31 anti-inflammatory, [27][28][29]32 antiarrhythmic, 33 antitumor 34 , anti HSV-1 35 anti-HIV 36,37 activities and act as inhibitors of acetylcholinesteras. 38 Structures of few previously reported biologically active 1,6-naphyridines (A-G) are shown in Figure 1.…”

Novel Tandem Aldol Intramolecular Cyclization of SubstitutedN-Benzylpiperidine-4-one: Synthesis of Novel-Type Nitrogen 2,8-Phenanthroline Heterocycles

“…The Michael addition reaction is one of the most facile and rapid methods for the synthesis 1,5‐dicarbonyl derivatives . These dicarbonyl derivatives can be used as convenient building blocks for constructing dyhydropyridine and pyridine systems , which have been shown to display various biological activities . Presently, we have studied reactions between N ‐substituted piperidine‐4‐ones ( 1 and 2 ) and series of chalcones ( 4–7 ) prepared following previously described literature method under the conditions of Michael addition.…”

Effect of Substituents in the Syntheses of Phenyl‐Substituted Dibenzonaphthyridines

“…Several anilinoquinolines were established as synthetic antimalarials and have been utilized as synthons in deriving various fused heterocycles such as dibenzonaphthyridines and indoloquinoline alkaloids . Research on naphthyridine chemistry has been expanded considerably in recent years in connection with the fact that these heterocycles exceptionally own a broad spectrum of their biological activities such as anti‐arrhythmic , anti‐analgesic , therapy of disease of human including AIDS , and cancer . Particularly, some dibenzonaphthyridines, that is, quinoline dimers, act as selective 3‐phosphoinositide‐dependent kinase‐I inhibitors .…”