Synthesis of new cis-fused tetrahydrochromeno[4,3-b]quinolines and their antiproliferative activity studies against MDA-MB-231 and MCF-7 breast cancer cell lines

Synthesis and Biological Evaluation of Amidinourea and Triazine Congeners as Inhibitors of MDA‐MB‐231 Human Breast Cancer Cell Proliferation

“…The IC50 values are summarised in Table 1 and were compared with the data reported for tamoxifen. 16 The three amidinureas 3d-f confirmed the data previously observed emerging as potent breast cancer inhibitors. In particular compound 3d, bearing a morpholine substituent on the amidinurea moiety showed IC50 = 0.76 M, close to that of tamoxifen, thus proving to be a valuable candidate for further development.…”

TBHP Promoted Cross‐Dehydrogenative coupling (CDC) Reaction: Metal/Additive‐Free Synthesis of Chromone‐Fused Quinolines

“…Particularly, quinolone‐annulated chromone scaffolds are the privileged structures of many pharmacologically active molecules and have attracted great attention to both synthetic and medicinal chemists. The derivatives of these compounds possess various biological activities such as cytotoxic, Progesterone and Estrogen receptors, Anti‐proliferative and Anti‐inflammatory activity . In spite of their biological importance, approaches in literature to the syntheses of these hetero‐fused chromones are limited.…”

Thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell apoptosis in breast cancer cells

“…Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum (FBS), penicillin-streptomycin-glutamine (x100) and 0.5% trypsin-EDTA solution were purchased from Invitrogen (Carlsbad, CA, USA). As described previously (10), the MCF-7 cell lines were maintained in DMEM supplemented with 10% FBS, 50 IU/ml penicillin and 50 µg/ml streptomycin and were grown at 37˚C in a humidified atmosphere with 5% CO 2 .…”