Synthesis of New Bis(3-hydroxy-4-pyridinone) Ligands as Chelating Agents for Uranyl Complexation

Abstract

Abstract:Five new bis(3-hydroxy-4-pyridinone) tetradentate chelators were synthesized in this study. The structures of these tetradentate chelators were characterized by 1 H-NMR, 13 C-NMR, FT-IR, UV-vis, and mass spectral analyses. The binding abilities of these tetradentate chelators for uranyl ion at pH 7.4 were also determined by UV spectrophotometry in aqueous media. Results showed that the efficiencies of these chelating agents are dependent on the linker length. Ligand 4b is the best chelator and suitable for further studies.

Uranium exposure increases spermatocytes metaphase apoptosis in rats: inhibitory effect of thymoquinone and N-acetylcysteine

“…Uranium persists for long period at the bio-ecological systems because of its long half-life time, various ways of exposure, magnification through the food chain, and combined metallic and radiation toxicities (Di Lella et al 2005;Briner 2010). Several chelating ligands have been used to hasten the urinary exertion of uranium and to reduce its toxicity (Jin et al 2016;Swami and Shrivastava 2016) but unfortunately, this therapeutic strategy faced many problems including exaggeration of the DU nephrotoxicity and the in vivo blockage of detoxification pathways (Briner 2010;Hao et al 2016). Unexpected lack of deleterious physiological effects was seen in rats after a chronic oral intake, for 9 months to mimic the chronic exposure of uranium-rich territories inhabitants (Dublineau et al 2014).…”