Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties

Inzunza, Débora; Covarrubias, Cristian; Marttens, Alfredo von; Leighton, Y; Carvajal, Juan Carlos; Valenzuela, Francisco; Díaz-Dosque, Mario; Méndez, Natalia; Martínez, Constanza; Pino, Ana María; Rodríguez, Juan ́Pablo; Cáceres, Mónica; Ph, Smith

doi:10.1002/jbm.a.34673

Cited by 44 publications

(24 citation statements)

References 53 publications

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“…The highest levels of cell differentiation markers (ALP activity and collagen secretion) in the present study were also found on the macro/mesoporous surface. Mesoporous structures possess excellent biocompatibility; mesoporous titania films provide suitable surfaces for MG63 cells to attach and proliferate, and silica coatings with highly ordered sub‐10 nm porosity accelerate early osteoblast adhesive response . Studies on the nonporous titanium, titanium with mesoporous TiO 2 coating, and titanium with Mg‐loaded mesoporous coating have demonstrated that the organized pore distribution, presence of nanoscale roughness, and developed titanium dioxide layer of the 3D mesoporous coating are associated with enhancement of adhesion and osteogenic differentiation in vitro .…”

Section: Discussionmentioning

confidence: 99%

Effects of the hierarchical macro/mesoporous structure on the osteoblast‐like cell response

Zhang

Elkhooly

Huang

et al. 2018

J Biomedical Materials Res

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To improve the success of medical devices, implants with strong surface bioactivity are urgently required. Coatings with a macroporous structure produced by micro-arc oxidation possess advantages, such as strong adhesion to substrate and excellent resistance to wear and corrosion. Mesoporous structures contain pores with sizes of 2-50 nm, which can endow the biomaterials with the ability to enhance osteogenesis and to be loaded with diverse drugs. Thus, in this study, we aimed to evaluate the effects of both macroporous and mesoporous structures using a hierarchical macro/mesoporous structure to modify the titanium implant surface. The behaviors of SaOS-2 human osteosarcoma cells on the macro/mesoporous structure, including initial adhesion, proliferation, alkaline phosphatase (ALP) activity, and collagen secretion, were investigated. Cells that attached on the macro/mesoporous surface showed the highest cell numbers and greatest spreading area after incubation for 1, 2, and 4 h compared with the polished smooth substrate and macroporous surface in the presence of fetal bovine serum (FBS). However, in the absence of FBS, cell adhesion on the polished substrate, macroporous structure, and macro/mesoporous structure did not differ significantly. Cell proliferation on the macroporous and macro/mesoporous surfaces increased compared with that on the smooth substrate surface. Furthermore, ALP activity and collagen secretion were enhanced on the macro/mesoporous structure. Our findings provided important insights into the cellular responses to macro/mesoporous structures in the field of implant surface modification. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1896-1902, 2018.

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Section: Discussionmentioning

confidence: 99%

Effects of the hierarchical macro/mesoporous structure on the osteoblast‐like cell response

Zhang

Elkhooly

Huang

et al. 2018

J Biomedical Materials Res

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“…The increased percent of the silica and calcium on the plasma treated CFR-PEEK implant surface could contribute to the increased bone to implant contact and bone formation at the plasma treated surfaces as silica particles highly improves the osteoblast adhesive responses and stimulates the osteogenic differentiation of stem cells, probably through a mechanic transduction mechanism Several studies have reported a higher rate and extent of bone formation adjacent to implants coated with micro sized bio ceramics (45)(46)(47)…”

Section: Discussionmentioning

confidence: 99%

The Effect of Atmospheric Plasma-Sprayed Peek Implants on Osseointegration

Mahrous

Mohamed

Ahmed

2018

Egyptian Dental Journal

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Objectives:The study evaluated the osseointegration of atmospheric plasma treated PEEK implant surfaces versus the untreated PEEK surfaces. Material & Methods:The PEEK implants were milled using carbon reinforced PEEK material with CAD-CAM milling machine. The implants were placed in 6 male mongrel dogs, each dog received 2 groups of PEEK implants. The control group consisted of untreated surface PEEK implants. The study group consisted of atmospheric plasma-sprayed PEEK implants. the implants were placed in the dog femur. After 12 weeks, the animals were sacrificed, and boneimplant sections were obtained for histological evaluations and bone-to-implant contact. Electron microscope scanning was performed to assess the topography of the surface of treated and untreated PEEK implant surface.Results: Qualitative evaluation of the stained histological sections of the PEEK implants demonstrated a well distributed bone in proximity to the atmospheric plasma-sprayed PEEK implant surface after 12 weeks of placements. The bone-to-implant contact showed a significant difference (P < 0.001) between treated and untreated PEEK implant surface. Conclusions:Within the limitation of the present study, it is concluded that the atmospheric plasma-sprayed surface treatment may improve the osseointegration of PEEK implant.

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“…Topography and, in particular, roughness, are determining factors in the initial stages of osseointegration (12). Topography determines processes such as protein adsorption and osteoblast adhesion (13). It has been proven that roughness promotes gene expression, activates integrins and increases the activity of alkaline phosphatase (14).…”

Section: Discussionmentioning

confidence: 99%

Topographic characterisation of dental implants for commercial use

et al. 2016

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BackgroundTo characterize the surface topography of several dental implants for commercial use.Material and MethodsDental implants analyzed were Certain (Biomet 3i), Tissue Level (Straumann), Interna (BTI), MG-InHex (MozoGrau), SPI (Alphabio) and Hikelt (Bioner). Surface topography was ascertained using a confocal microscope with white light. Roughness parameters obtained were: Ra, Rq, Rv, Rp, Rt, Rsk and Rku. The results were analysed using single-factor ANOVA and Student-Neuman-Keuls(p<0.05) tests.ResultsCertain and Hikelt obtained the highest Ra and Rq scores, followed by Tissue Level. Interna and SPI obtained lower scores, and MG-InHex obtained the lowest score. Rv scores followed the same trend. Certain obtained the highest Rp score, followed by SPI and Hikelt, then Interna and Tissue Level. MG-InHex obtained the lowest scores. Certain obtained the highest Rt score, followed by Interna and Hikelt, then SPI and Tissue Level. The lowest scores were for MG-InHex. Rsk was negative (punctured surface) in the MG-InHex, SPI and Tissue Level systems, and positive (pointed surface) in the other systems. Rku was higher than 3 (Leptokurtic) in Tissue Level, Interna, MG-InHex and SPI, and lower than 3 (Platykurtic) in Certain and Hikelt.ConclusionsThe type of implant determines surface topography, and there are differences in the roughness parameters of the various makes of implants for clinical use. Key words:Implants for clinical use, topography, confocal microscopy.

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Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties

Cited by 44 publications

References 53 publications

Effects of the hierarchical macro/mesoporous structure on the osteoblast‐like cell response

Effects of the hierarchical macro/mesoporous structure on the osteoblast‐like cell response

The Effect of Atmospheric Plasma-Sprayed Peek Implants on Osseointegration

Topographic characterisation of dental implants for commercial use

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