Synthesis of N-substituted thioamides of benzoic acids under microwave activation

Фазылов, С. Д.; Нуркенов, О. А.; Akhmetkarimova, Zh. S.; Zhienbaeva, D. R.

doi:10.1134/s1070363212040317

Cited by 6 publications

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References 3 publications

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“…have report the oxidative coupling of two different aliphatic primary amines into thioamides by elemental sulfur under solvent‐free conditions at 130 o C, it also report three‐component synthesis of thioamides from alkynes, elemental sulfur, and aliphatic amines by using pyridine 0.5 mL at 60–100 and time required 24 hrs . In literature, thioamides are synthesized from nitrile involving thioacetic acid in presence of calcium hydroxide, gaseous H 2 S in presence of anion‐exchange resin (Dowex 1X8, SH‐form), microwave assisted solvent free, NaSH and MgCl 2 in DMF sodium hydrogen sulfide and diethylamine . H. R. Darabi, et al.…”

Section: Introductionmentioning

confidence: 99%

Simple and Highly Efficient Synthesis of Thioamide Derivatives Using β‐Cyclodextrin as Supramolecular Catalyst in Water

2018

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A simple, straightforward and highly efficient approach for the synthesis of thioamide derivatives in water at 100 oC has been developed. Total 22 compounds were prepared via a one‐pot multicomponent reaction between substituted aldehydes, sulfur powder and secondary amines by using recyclable catalyst β‐cyclodextrin indicating the broad substrate scope of this method. The salient features of the present protocol are water as a green solvent, non‐toxic catalyst, good to excellent yields of products, operational simplicity, eco‐friendliness and easy isolation of products. The used catalyst was recovered and reused several times without significant loss of catalytic activity, which is an essential parameter of green synthesis.

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Section: Introductionmentioning

confidence: 99%

Simple and Highly Efficient Synthesis of Thioamide Derivatives Using β‐Cyclodextrin as Supramolecular Catalyst in Water

2018

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Catalyst‐ and Solvent‐Free Thioamidation of Aromatic Aldehydes through a Willgerodt‐Kindler Reaction

Kale

Dalal

2022

ChemistrySelect

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A simple, straightforward, and highly efficient approach has been developed to synthesize thioamide derivatives under catalyst‐ and solvent‐free conditions at 100 °C/room temperature. Total 51 thioamides were synthesized via a one‐pot multicomponent Willgerodt‐Kindler reaction between substituted aromatic aldehydes, elemental sulfur powder and amines with 70–98 % yield within 20–70 min using cyclic secondary amines and 1.5–24 h using aliphatic primary and secondary amines. The cyclic secondary amines react faster than aliphatic amines. Twenty‐one newer compounds were prepared and characterized by 1H NMR, 13C NMR, HRMS. Mild reaction conditions, good yields, and a wide range of reactions demonstrate the excellent synthetic utility of this method. The developed protocol showed that there is no need to collect, purify, recycle, and remove the solvent after the reaction is complete. Reaction rates are generally high due to the high availability of reactants, i. e., shortens the reaction time, is environmentally friendly, and which makes the overall process more sustainable and economical.

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Synthesis of Thioamides

Murai

2019

Chemistry of Thioamides

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Synthesis of N-substituted thioamides of benzoic acids under microwave activation

Cited by 6 publications

References 3 publications

Simple and Highly Efficient Synthesis of Thioamide Derivatives Using β‐Cyclodextrin as Supramolecular Catalyst in Water

Simple and Highly Efficient Synthesis of Thioamide Derivatives Using β‐Cyclodextrin as Supramolecular Catalyst in Water

Catalyst‐ and Solvent‐Free Thioamidation of Aromatic Aldehydes through a Willgerodt‐Kindler Reaction

Synthesis of Thioamides

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