Synthesis of N-alkyl derivatives and photochemistry of nitro (E)-3-azachalcones with theoretical calculations and biological activities

Synthesis, Configuration, and Antimicrobial Properties of Novel Substituted and Cyclized ‘2′,3″‐Thiazachalcones’

“…Compared to the findings of an earlier study with analogous azachalcones lacking a thiophenyl ring, compounds 1 -6 exhibited better antimicrobial activities, especially against Gram-negative bacteria [7]. Further, compounds 4 -6 were active against Yersinia pseudotuberculosis, in contrast to previous analogues lacking the thiophenyl ring [7].…”

“…Further, compounds 4 -6 were active against Yersinia pseudotuberculosis, in contrast to previous analogues lacking the thiophenyl ring [7]. Similarly, compounds 1 and 2 were active against Staphylococcus aureus, while their analogues without a thiophenyl ring were previously shown to be inactive [7]. The solvent control (DMSO) showed no inhibition effect on all test microorganisms under the experimental conditions.…”

“…In consideration of the antimicrobial properties of azachalcones and its derivatives, we recently prepared a series of new methyl-substituted 2',3''-thiazachalcones, and performed some structure -activity-relationship (SAR) studies [7]. The present investigation deals with the synthesis, spectroscopic characterization, and biological activities of a series of new 2',3''-thiazachalcone derivatives, compounds 1 -9 (see Scheme below) 1 ).…”

“…In the dimerization reactions of compounds 1 -3, theoretically eleven different isomers can be obtained according to kinetics theory [7] [19 -21]. We calculated the heat of formation of six head-to-head isomers (a -f) of compounds 7 -9 by means of the PM3 semi-empirical method ( Table 3).…”

Comparative Study of Synthesis and Spectral Studies of Thiophenyl Carboxylate Derivatives by Microwave Irradiation and Conventional Method

“…Chalcones and its derivatives have attracted increasing attention due to numerous pharmacological applications. They have displayed a broad spectrum of pharmacological activities, among which antimalarial [1][2][3][4] , antifungal 5,6 , antimicrobial 7 , larvicidal 8 , anticonvulsant 9 , antioxidant [10][11][12] activities. The IR spectrum supported the data showing the characteristic band for C=O at 1645 to 1655 and C=C at around 1570 to 1600 cm -1 and aromatic CH band between 3000 to 3100 cm -1 and aliphatic CH band stretching between 2900 to 3000 cm -1 and band for the C-S group is in the range of 600 to 800 cm -1 .…”