Synthesis of N-(3-alkyl-4-phenyl-3H-thiazol-2-ylidene)Benzamide Derivatives by Reaction of Phenacyl Bromide and Aroyl Isothiocyanates in the Presence of Primary Amines

Abstract

A three-component and one-pot reaction between phenacyl bromide and aroyl isothiocyanates in the presence of primary amines gave N-(3-alkyl-4-phenyl-3H-thiazol-2-ylidene)benzamide derivatives in good yields.

Divergent Approach to Thiazolylidene Derivatives: A Perspective on the Synthesis of a Heterocyclic Skeleton from β-Amidothioamides Reactivity

“…The value of a domino reaction can be correlated with the number of bonds generated in such a process in one single event. In this context, the synthesis of structures containing a privileged thiazoline framework becomes important because of their biological and pharmacological properties . In particular, some thiazolylidenes with general structure I and II have been reported as the basis for cannabinoid receptor ligands (Figure ).…”