Synthesis of multiresponsive β‐cyclodextrin nanocomposite through surface RAFT polymerization for controlled drug delivery

Abstract

In this study, a unique magnetic, pH, and thermo‐responsive hydrogel nanocomposite was synthesized via surface reversible addition fragmentation chain transfer (RAFT) copolymerization of acrylic acid (AA) and N‐isopropyl acrylamide (NIPAM) in the presence of magnetic β‐cyclodextrin (β‐CD). The nanocomposite demonstrated a pH‐responsiveness behavior at pHs 3 and 9. Moreover, swelling behaviors of nanocomposite were measured in solutions with various temperatures. Furthermore, the nanocomposites exhibited high swelling capacity by applying an external magnetic field because of the presence of Fe3O4 nanoparticles in the polymer structure. Besides, the doxorubicin (DOX) loading and releasing behaviors of the hydrogel nanocomposites were studied because of the stimuli‐responsive properties of the synthesized carriers. The adsorption of DOX obeyed a pseudo‐second‐order model and fitted well to the Langmuir isotherm model with the maximum adsorption capacity uptake of 291 mg g−1. In conclusion, the hydrogel nanocomposites were found to be as potential nanocarriers for use in controlled release applications.

Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology

“…Interpretation of the XRD patterns of the amplopolymer nanocomposite indicated that there was a tiny shift in the peak heights without a change in the d-spacing of the peaks. The disappearance of drug peaks in the nanocomposites indicates that the drug was incorporated between the polymer molecules and amorphous [23,24].…”

Injectable Nanocomposite Hydrogels for Cancer Therapy

“…[ 91 ] In addition, unique stimulation‐responsive hydrogel nanocomposites were prepared by the surface reversible addition of acrylic acid and N ‐isopropylacrylamide on chitosan and the in situ synthesis of magnetic Fe 3 O 4 NPs. [ 153 ] This preparation method is simple and can freely adjust the size of nanoparticles and then adjust the strength of the composite hydrogel, adjustability may expand its application in the field of oncology therapy.…”

“…[ 106 ] Besides, NIR/pH‐responsive NHs, [ 100,143,148 ] NHs responsive to temperature and pH also play a huge role in the medical field. [ 126,153 ] In addition to the double‐response NHs list above, there are triple response NHs either, under the in‐depth research of scientists, the novel NHs with excellent pH, thermo, and magnetic responsive were fabricated. [ 134,153,167 ] Li et al.…”

“…[ 126,153 ] In addition to the double‐response NHs list above, there are triple response NHs either, under the in‐depth research of scientists, the novel NHs with excellent pH, thermo, and magnetic responsive were fabricated. [ 134,153,167 ] Li et al. proposed a modular strategy for the synthesis of cationic NHS with tunable responsiveness, versatility, and biodegradability.…”

Magnetic graphene oxide grafted with different hydrophobic chain lengths low‐generation polyamidoamine dendrimers for adsorption of Pb(II) and Hg(II) in aqueous solution

“…Therefore, it is highly urgent to exploit a high efficient and environmental friendly method for Hg(II) and Pb(II) heavy metal ions removal. Among all the water treatment techniques, adsorption has been considered as a promising method with the flexibility of operational process as well as the economic efficiency . Therefore, it is very necessary to improve the performance of absorbents and develop new absorbents.…”