Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology

Abstract

Introduction. Polymer nanoparticles are a key tool to deliver drugs to specific sites and to increase drug bioavailability. Aim. This research aims to use poly amide-disulfide nanoparticles as drug delivery systems. Method. Amlodipine (Amlop) was used as a model, forming Amlop-polymer nanocomposites. In this work, we investigated the effect of independent variables (polymer, Fe3+, Al3+, and pH) on the dependent variables (loading efficiency (%LE), zeta potential, and particle size). Nanocomposites were prepared by an inotropic method. Nanocomposites were characterized by powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), and a release study. Results. From the XRD data, the Amlop-polymer nanocomposite shows semi crystallinity. In addition, the disappearance of drug peaks indicates that the drug was incorporated between the polymer molecules and was amorphous in behavior. The FTIR for the nanocomposite shows the functional group of the drug, which indicates the incorporation of Amlop into the nanocomposite. From FE-SEM, the results showed that our nanocomposites have an average particle size of approximately 130 nm. The release of amlodipine from the Amlop-polymer nanocomposite was found to be controlled, with approximately 85% within approximately 24 hours. Conclusion. The amide-disulfide polymer nanoparticles are promising carriers for different types of drugs.

Methotrexate-Polymer Nanocomposites for Targeted Pulmonary Drug Delivery

“…The stirring was maintained for 16 h. Following that, the final products were centrifuged at 11,000 rpm and room temperature (25 °C) for 25 min to allow separation of the nanoparticles. The final product was dried in an oven to obtain the final dry powder [21,[23][24].…”

Quality by Design for the Synthesis and Optimisation of Arginine-Poly(Ester-Amide) Nanocapsules as Promising Carriers for Nose-Brain Delivery of Carbamazepine

“…They can rapidly cross the physiological barriers and reach the target sites at sufficient drug concentrations. In addition, their use is generally associated with fewer adverse effects when compared to many other drug delivery systems [1][2][3][4]. The use of a polymeric nanocapsules delivery system, nevertheless, requires the control of several features of the polymeric nanocapsules such as their composition, entrapment efficiency, loading efficiency, size distribution, drug release profile and stability [2][3][4][5][6][7][8].…”

“…In addition, their use is generally associated with fewer adverse effects when compared to many other drug delivery systems [1][2][3][4]. The use of a polymeric nanocapsules delivery system, nevertheless, requires the control of several features of the polymeric nanocapsules such as their composition, entrapment efficiency, loading efficiency, size distribution, drug release profile and stability [2][3][4][5][6][7][8]. Several factors, especially parameters used in the synthesis procedures, have dramatic effects on the quality and effectiveness of particular nanocapsules samples.…”