“…In 1987, the drugs primaquine and amodiaquine were employed as ligands in the synthesis of 32 metal complexes and two of those were based on gold (III). All compounds were found to be active against P. falciparum (Table 1) to the same extent as the parental drugs [41]. Attaching a gold-containing fragment to chloroquine (CQ) results in a strong modification of the electronic properties.…”
Section: Gold Complexes As Antimalarial Agentsmentioning
“…In 1987, the drugs primaquine and amodiaquine were employed as ligands in the synthesis of 32 metal complexes and two of those were based on gold (III). All compounds were found to be active against P. falciparum (Table 1) to the same extent as the parental drugs [41]. Attaching a gold-containing fragment to chloroquine (CQ) results in a strong modification of the electronic properties.…”
Section: Gold Complexes As Antimalarial Agentsmentioning
“…Biological activities of organotin compounds as biocide, [8] antitumor, [9] schizonticidal and antimalarial [10] have been reported. Also, derivatives with Schiff bases have potential use as amoebicidal agents.…”
“…A number or transition metals e.g. Rh, Ru [4] and Au [5] have been coordinated to chloroquine and other aminoquinolines [6]. It has also been shown that ferrocene [7] and a ruthenocene [8] unit can also be incorporated into the aminoalkyl side chain of chloroquine.…”
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