Synthesis of Mannich type products via a three-component coupling reaction

TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media

“…It is reasonable to assume that TiO 2 NPs are coordinated to the oxygen atom of the aromatic aldehyde 2 activating it for nucleophilic attack [39]. Knoevenagel condensation between 2 and enamine 6, previously formed from the reaction of dimedone (3) and ammonium acetate (4), generates alkene 7.…”

Efficient Synthesis of β-Acetamido Ketones by Silver(I) Triflate-Catalyzed Multicomponent Reactions

“…10 Recently, another new procedure for the formation of β-acetamido ketones through the MCRs of acetophenone, arylaldehyde, and acetyl chloride in acetonitrile has been developed. [11][12][13][14][15][16][17][18][19][20][21] This reaction has been extensively studied with the use of a variety of catalysts and reagents such as 20 and Amberlyst-15.…”

SiO2-NaHSO4 as an Efficient Reusable Heterogeneous Catalyst for the One-Pot Three-Component Synthesis of Octahydro-quinazolin-2,5-diones in Water

“…Multicomponent reactions (MCRs) are very important for the construction of many heterocyclic compounds [1] and this strategy has been used effectively in the synthesis of many biologically active substances and natural products [2]. The synthesis of octahydro-quinazolin-2,5-diones has attracted the attention of chemists because of their highly potent antibacterial activity against many kinds of bacteria including Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa [3].…”