a b s t r a c t Ba(OH) 2 catalyzed simple and efficient one-pot four-component reaction of Meldrums acid, ethyl acetoacetate, hydrazine hydrate, and aromatic aldehydes to give 3-methyl-4-aryl-4,5-dihydro-1H-pyrano[2,3-c]pyrazol-6-ones in refluxing water is reported. The yields are high and the reactions go to completion in 1-2 h.
a b s t r a c tNovel pyrano [2,3-d]pyrimidine-2,4,7-triones were synthesized in 90-97% yield via a three-component reaction of an aromatic aldehyde, Meldrums acid, and barbituric acid in the presence of 10 mol % K 2 CO 3 under microwave irradiation. This is the first protocol to be reported for the synthesis of title compounds and the significant features of the present protocol are simplicity, high yields, short reaction time, involvement of aqueous work-up procedure, environmentally benign nature, and no chromatographic purification.
ZnO has been shown to be an inexpensive, efficient, readily available, and mild catalyst for a one-pot fourcomponent synthesis of some novel octahydroquinolindione-3-carboxylic acid ethyl esters using diethylmalonate, dimedone, ammonium acetate, and appropriate aromatic aldehydes in water at reflux. ZnO acts as a recyclable heterogeneous catalyst to afford the products in excellent yield in short reaction duration.
a b s t r a c tNovel pyrano [2,3-d]pyrimidine-2,4,7-triones were synthesized in 90-97% yield via a three-component reaction of an aromatic aldehyde, Meldrums acid, and barbituric acid in the presence of 10 mol % K 2 CO 3 under microwave irradiation. This is the first protocol to be reported for the synthesis of title compounds and the significant features of the present protocol are simplicity, high yields, short reaction time, involvement of aqueous work-up procedure, environmentally benign nature, and no chromatographic purification.
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