Synthesis of magnetite hydrosols in inert atmosphere

German, Sergey V.; Inozemtseva, Olga A.; Маркин, А. В.; Metvalli, Kh.; Хомутов, Г.Б.; Gorin, Dmitry A.

doi:10.1134/s1061933x13040042

Cited by 36 publications

(22 citation statements)

References 28 publications

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“…In this work, the method described previously by Massart was used for iron oxide nanoparticle synthesis [ 29 ]. Synthesis was carried out using the setup described in reference [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

et al. 2018

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Multilayer capsules of 4 microns in size made of biodegradable polymers and iron oxide magnetite nanoparticles have been injected intravenously into rats. The time-dependent microcapsule distribution in organs was investigated in vivo by magnetic resonance imaging (MRI) and ex vivo by histological examination (HE), atomic absorption spectroscopy (AAS) and electron spin resonance (ESR), as these methods provide information at different stages of microcapsule degradation. The following organs were collected: Kidney, liver, lung, and spleen through 15 min, 1 h, 4 h, 24 h, 14 days, and 30 days after intravenous injections (IVIs) of microcapsules in a saline buffer at a dosage of 2.5 × 109 capsule per kg. The IVI of microcapsules resulted in reversible morphological changes in most of the examined inner organs (kidney, heart, liver, and spleen). The capsules lost their integrity due to degradation over 24 h, and some traces of iron oxide nanoparticles were seen at 7 days in spleen and liver structure. The morphological structure of the tissues was completely restored one month after IVI of microcapsules. Comprehensive analysis of the biodistribution and degradation of entire capsules and magnetite nanoparticles as their components gave us grounds to recommend these composite microcapsules as useful and safe tools for drug delivery applications.

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“…In this work, the method described previously by Massart was used for iron oxide nanoparticle synthesis [ 29 ]. Synthesis was carried out using the setup described in reference [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

et al. 2018

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“…Magnetic nanoparticles were obtained by chemical precipitation from di-and trivalent salts of iron in the presence of the base [24,25]. Initially, 1.3 g of FeCl 3 •6H 2 O and 0.478 g of FeCl 2 •4H 2 O were dissolved in water under room temperature with mixing.…”

Section: Magnetite Nanoparticle Synthesismentioning

confidence: 99%

Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast

et al. 2020

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Magnetic contrast agents are widely used in magnetic resonance imaging in order to significantly change the signals from the regions of interest in comparison with the surrounding tissue. Despite a high variety of single-mode T1 or T2 contrast agents, there is a need for dual-mode contrast from the one agent. Here, we report on the synthesis of magnetic submicron carriers, containing Fe3O4 nanoparticles in their structure. We show the ability to control magnetic resonance contrast by changing not only the number of magnetite nanoparticles in one carrier or the concentration of magnetite in the suspension but also the structure of the core–shell itself. The obtained data open up the prospects for dual-mode T1/T2 magnetic contrast formation, as well as provides the basis for future investigations in this direction.

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“…PDDA of different average MW (low 100-200 kDa, medium 250-350 and high 400-500 kDa) with concentration 2 mg/ml in aqueous 0,15 М NaCl solution and a hydrosol of MNPs were used for modification of the HC-MFs internal structure. MNPs were synthesized by using the method described by German at al [33]. and stabilized by citric acid.…”

Section: Appendix B: Characterization Of Pdda and Magnetite Nanopartimentioning

confidence: 99%

Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

Noskov

Zanishevskaya²,

Shuvalov³

et al. 2019

Opt. Express

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Optical fibers are widely used in bioimaging systems as flexible endoscopes that are capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique that allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), which paves the way for combing MRI and optical bioimaging. Our approach is based on layer-by-layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating, along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI to open novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.

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Synthesis of magnetite hydrosols in inert atmosphere

Cited by 36 publications

References 28 publications

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast

Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

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