Synthesis of magnetic nanoparticles in bicontinuous microemulsions. Effect of surfactant concentration

Loo, Ana L.; Pineda, María Guadalupe; Saade, H.; Treviño, María E.; López, Raúl G.

doi:10.1007/s10853-008-2581-6

Cited by 27 publications

(13 citation statements)

References 27 publications

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“…Precipitation within reverse microemulsions has also been successfully executed. While this method does produce MNPs of narrower size distribution over aqueous precipitation, microemulsion is generally beset with low yields [7]. Recently, thermal decomposition of organometallic compounds has gained considerable attention [8].…”

Section: Techniques For Synthesis Of Mnpsmentioning

confidence: 99%

Cancer theranostics: the rise of targeted magnetic nanoparticles

Cole¹,

Yang²,

David³

2011

Trends in Biotechnology

372

221

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Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has grown considerably over the past two decades. This excitement is driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging (MRI). The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy – giving rise to the distinction of MNPs as potential “theranostics”. Here we review both the key technical principles of MNPs and the ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of MNPs and offer considerations for their future development.

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Section: Techniques For Synthesis Of Mnpsmentioning

confidence: 99%

Cancer theranostics: the rise of targeted magnetic nanoparticles

Cole¹,

Yang²,

David³

2011

Trends in Biotechnology

372

221

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“…This strategy has notable limitations yielding monodispersity [31]. The microemulsion method does produce MNS of narrower size distribution compared to aqueous precipitation, but suffers from low yields [32]. Recently, the thermal decomposition/reduction method has gained considerable attention since this technique offers fine control over the final particle size, shape, and crystal structure compared to other methods and is scalable [33, 34].…”

Section: Synthesis and Characteristics Of Mns: Prospects For Theranmentioning

confidence: 99%

Theranostic Magnetic Nanostructures (MNS) for Cancer

Nandwana

Chu³

et al. 2015

Cancer Treatment and Research

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Despite the complexities of cancer, remarkable diagnostic and therapeutic advances have been made during the past decade, which include improved genetic, molecular, and nanoscale understanding of the disease. Physical science and engineering, and nanotechnology in particular, have contributed to these developments through out-of-the-box ideas and initiatives from perspectives that are far removed from classical biological and medicinal aspects of cancer. Nanostructures, in particular, are being effectively utilized in sensing/diagnostics of cancer while nanoscale carriers are able to deliver therapeutic cargo for timed and controlled release at localized tumor sites. Magnetic nanostructures (MNS) have especially attracted considerable attention of researchers to address cancer diagnostics and therapy. A significant part of the promise of MNS lies in their potential for “theranostic” applications, wherein diagnostics makes use of the enhanced localized contrast in magnetic resonance imaging (MRI) while therapy leverages the ability of MNS to heat under external radio frequency (RF) field for thermal therapy or use of thermal activation for release of therapy cargo. In this chapter, we report some of the key developments in recent years in regard to MNS as potential theranostic carriers. We describe that the r2 relaxivity of MNS can be maximized by allowing water (proton) diffusion in the vicinity of MNS by polyethylene glycol (PEG) anchoring, which also facilitates excellent fluidic stability in various media and extended in vivo circulation while maintaining high r2 values needed for T2-weighted MRI contrast. Further, the specific absorption rate (SAR) required for thermal activation of MNS can be tailored by controlling composition and size of MNS. Together, emerging MNS show considerable promise to realize theranostic potential. We discuss that properly functionalized MNS can be designed to provide remarkable in vivo stability and accompanying pharmacokinetics exhibit organ localization that can be tailored for specific applications. In this context, even iron-based MNS show extended circulation as well as diverse organ accumulation beyond liver, which otherwise renders MNS potentially toxic to liver function. We believe that MNS, including those based on iron oxides, have entered a renaissance era where intelligent synthesis, functionalization, stabilization, and targeting provide ample evidence for applications in localized cancer theranostics.

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“…Since the shape of reverse micelle depends on the w-value, i.e. decreasing the w-value changes the spherical shape to cylindrical and lamellar shapes [17], it appears that the concentration of iron salts could control the shape of SPIONs in w/o microemulsion.…”

Section: Effect Of Iron Salt Concentrationmentioning

confidence: 99%

“…In this procedure, surfactantcovered water pools offer a unique microenvironment for the nucleation and controlled growth of SPIONs [15,16]. So far, different preparation routes have been reported for emulsionmediated synthesis of magnetite (Fe 2 þ Fe 3 þ 2 O 4 ) and maghemite (Fe 3 þ 2 O 3 ) NPs [17][18][19][20][21][22][23][24][25][26][27][28][29][30]; in this case, it is clear that, type and concentration of either iron salts or reducing agent, the molar ratio of water to surfactant, temperature, and the type of surfactants have significant influence on physicochemical properties of obtained SPIONs.…”

Section: Introductionmentioning

confidence: 99%