Size-controlled synthesis of superparamagnetic iron oxide nanoparticles and their surface coating by gold for biomedical applications

In recent decades, magnetic iron nanoparticles (NPs) have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.

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“…To protect the in vivo environment from these toxic byproducts, biocompatible and rigid coatings such as gold have been employed [84].…”

Section: Surface Modificationmentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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“…Among various synthesizing methods of iron oxide nanoparticles water-in-oil microemulsion methods have been of a great interest to precisely control the size and size distribution of various nanoparticles (7 -10 nm) (Maleki et al 2012). Not only, microemulsions show a great variety of structures, such as globular, spherical aggregates, bi-continuous and tubular bi-continuous (Okoli et al 2012;Wu et al 2008;Oliveira et al 2004) with particle diameters under 1400 Å, typically in the order of 100 Å (Oliveira et al 2004).…”

Section: Microemulsionmentioning

confidence: 99%

Synthesis, Characterization and Applications of Iron Oxide Nanoparticles - a Short Review

Campos

Pinto

Oliveira

et al. 2015

J.Aerosp. Technol. Manag.

191

100

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Iron oxide is a mineral compound that shows different polymorphic forms, including hematite (α-Fe 2 O 3 ), magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ). Solid propulsion technology nanoparticulate materials, such as hematite and maghemite, exhibit high performance on thermal decomposition of ammonium perchlorate. The enhanced catalytic effect of metallic iron oxide nanoparticles is attributed to their particle size, more active sites and high surface area, which promotes more gas adsorption during thermal oxidation reactions. Nowadays, metallic iron nanoparticles can be synthesized via numerous methods, such as co-precipitation, sol-gel, microemulsion, or thermal decomposition. Although there are data on these synthetic methods in the literature, there is a lack of details related to nanoparticulate oxides and to their characterization techniques. In this context, this short review based on scientific papers, including data from the last two decades, presents methods for obtaining nanoparticulate iron oxides as well as the main aspects of the different characterization techniques and also about the decomposition aspects of these nanomaterials. Morphologies and structures of iron oxides can be characterized through transmission electron microscopy, scanning electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy. As for textural properties, they are usually determined by physical adsorption techniques.

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“…Various methods are available for synthesis of magnetic nanoparticles such as co-precipitation [ [6][7][8], sol-gel synthesis [9,10], and microemulsion [11][12][13]. The most common is the co-precipitation method [14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of pH and Time on The Stability of Superparamagnetic Maghemite Nanoparticle Suspensions

Nurdin¹,

Ridwan²,

Satriananda³

2016

MATEC Web of Conferences

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Abstract. Maghemite (γ-Fe 2 O 3 ) nanoparticles have been synthesized using a chemical co-precipitation method. The morphology and particle size is characterized using Transmission Electron Microscopy (TEM), and magnetic characterization using Alternating Gradient Magnetometry (AGM). The stability of the maghemite nanoparticles suspension were studied at different pH and time of storage. Dynamic Light Scattering (DLS) and Zeta Potential were conducted to determine the stability of the suspensions. TEM observation showed that the particles size is 9.6 nm and have spherical morphology. The particles showed superparamagnetic behavior with saturation magnetization 25.5 emu/g. The suspensions are stable in the acidic condition at pH 4 and alkaline condition at pH 10. The suspensions remain stable after 4 weeks of storage.

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Size-controlled synthesis of superparamagnetic iron oxide nanoparticles and their surface coating by gold for biomedical applications

Cited by 109 publications

References 55 publications

A biotechnological perspective on the application of iron oxide nanoparticles

A biotechnological perspective on the application of iron oxide nanoparticles

Synthesis, Characterization and Applications of Iron Oxide Nanoparticles - a Short Review

The Effect of pH and Time on The Stability of Superparamagnetic Maghemite Nanoparticle Suspensions

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