Synthesis of Lactose‐Based S‐Linked Sialylmimetics of α(2,3)‐Sialosides.

Liakatos, Angela; Kiefel, Milton J.; Itzstein, Mark von

doi:10.1002/chin.200412199

Cited by 1 publication

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“…As carbohydrates are typically T‐cell‐independent B cell antigens, to generate high titers of anti‐glycan IgG antibodies, it is important to link the carbohydrates to an immunogenic carrier capable of activating helper T cells . We have previously demonstrated that bacteriophage Qβ is a powerful carrier to deliver tumor associated carbohydrate antigens .…”

Section: Resultsmentioning

confidence: 99%

Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti‐pertussis Vaccine

et al. 2020

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With the infection rate of Bordetella pertussis at a 60‐year high, there is an urgent need for new anti‐pertussis vaccines. The lipopolysaccharide (LPS) of B. pertussis is an attractive antigen for vaccine development. With the presence of multiple rare sugars and unusual glycosyl linkages, the B. pertussis LPS is a highly challenging synthetic target. In this work, aided by molecular dynamics simulation and modeling, a pertussis‐LPS‐like pentasaccharide was chemically synthesized for the first time. The pentasaccharide was conjugated with a powerful carrier, bacteriophage Qβ, as a vaccine candidate. Immunization of mice with the conjugate induced robust anti‐glycan IgG responses with IgG titers reaching several million enzyme‐linked immunosorbent assay (ELISA) units. The antibodies generated were long lasting and boostable and could recognize multiple clinical strains of B. pertussis, highlighting the potential of Qβ‐glycan as a new anti‐pertussis vaccine.

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Section: Resultsmentioning

confidence: 99%