Synthesis of Janus and Patchy Particles Using Nanogels as Stabilizers in Emulsion Polymerization

Lotierzo, Andrea; Longbottom, Brooke W.; Lee, Wai Hin; Bon, Stefan Antonius Franciscus

doi:10.1021/acsnano.8b06557

Cited by 45 publications

(43 citation statements)

References 62 publications

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“…As further validation, when the amount of crosslinking points [poly(glycidyl methacrylate)% (PGMA%)] was increased from 4% to 8%, the corresponding T m and crystallization temperature ( T c ) values decreased in linear regression patterns (Figure c), which was matched by their enthalpy energies ( H m and H c ) (Figure d; Figure S3a, Supporting Information). The range of T c was typically lower than T m because polymer crystallization occurred at a temperature lower than T m .…”

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confidence: 88%

Development of a Shape‐Memory Tube to Prevent Vascular Stenosis

et al. 2019

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Figure S1 and Video S1, Supporting Information). Vessel-damage-free deployment requires the shape recovery of a graft through circumferential tube expansion by ≈40%-50% to fit the host vessel after insertion (Videos S1-S3, Supporting Information). Hence, a new class of shape memory polymer (SMP) library was synthesized through ring opening polymerization [3] with ε-caprolactone (CL) and glycidyl methacrylate (GMA) monomers (Figure 1a; Figure S2, Supporting Information). Vessel property-matching optimization necessitated a combinatorial design strategy [4] to produce tunable SMP properties through a series of development steps (Figure 1b-g). First, the idea of decreasing the shape recovery temperature, which was represented by melting temperature (T m ), to the body temperature range was validated [5] by the differential scanning calorimetry (DSC) (Figure 1b). T m decreased from the temperature of the base poly(ε-caprolactone) (PCL) to that of our SMPs because crosslinking reduced the crystallinity of PCL. This effect was more dominant compared to the increase in the tightness of the polymer chains owing to Inserting a graft into vessels with different diameters frequently causes severe damage to the host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with diameters less than 6 mm, because of vessel occlusion caused by disturbed blood flow following fast clotting. Herein, successful patency in the deployment of an ≈2 mm diameter graft into a porcine vessel is reported. A new library of property-tunable shape-memory polymers that prevent vessel damage by expanding the graft diameter circumferentially upon implantation is presented. The polymers undergo seven consecutive cycles of strain energy-preserved shape programming. Moreover, the new graft tube, which features a diffuser shape, minimizes disturbed flow formation and prevents thrombosis because its surface is coated with nitric-oxide-releasing peptides. Improved patency in a porcine vessel for 18 d is demonstrated while occlusive vascular remodeling occurs. These insights will help advance vascular graft design. Biomedicine

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confidence: 88%

Development of a Shape‐Memory Tube to Prevent Vascular Stenosis

et al. 2019

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“…This is particularly interesting as in previous work from our group we observed that the formation of colloidal suprastructures (i.e. patchy particles) was favored in a pH range where nanogel clustering was observed, 26 which is considerably different from what observed for ionic strength increase.…”

Section: Resultsmentioning

confidence: 59%

“…The nanogels were prepared as described previously. 26 Table 1 summarizes their key properties. The MMA/MAA molar ratio was 1.8/1.0, and the average degree of polymerization (DP) was 17 and 10 respectively for the first (hydrophilic) and second (hydrophobic) block.…”

Section: Resultsmentioning

confidence: 99%

“…25 Recently, we showed that crosslinked polymer nanoparticles, or nanogels, can be used as a class of Pickering stabilizers to synthesize anisotropic polymer colloids of Janus and patchy particle morphology. 26 In this paper, we would like to investigate the role of inert electrolyte, or salt, on the Pickering emulsion polymerization process in which nanogels are used as stabilizer. The addition of electrolytes has an impact on emulsion polymerization reactions from a mechanistic standpoint.…”

Section: Introductionmentioning

confidence: 99%

“…As described above, we recently showed that by using nanogels we can open up the particle morphology window away from fully armored structures into Janus and Patchy morphologies. 26 The objective of the work reported here is to explore the role of salt in regulating particle morphology.…”

Section: Introductionmentioning

confidence: 99%

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