Synthesis of Indoloquinolones, Triazoloindoloquinolines and Its Derivatives.

Abstract

Fused pyridine derivativesFused pyridine derivatives R 0450 Synthesis of Indoloquinolones, Triazoloindoloquinolines and Its Derivatives. -A variety of novel indoloquinolones, triazoloindoloquinolines (IX) and azetidinylamino-substituted indoloquinolines [cf. (XIII)] are synthesized from hydrazinoquinolines (I) involving thermal Fischer indolization as the key step [→(V)]. Selected compounds are evaluated for their antibacterial activity. -(MULWAD*, V. V.; LOHAR, M. V.; Indian J.

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

“…Yield: 85%; brown solids; mp 333.0–334.0 °C (decomposed); 1 H NMR (300 MHz, DMSO- d 6 ) δ 12.48 (s, 1H), 11.30 (s, 1H), 8.19 (d, J = 7.7 Hz, 1H), 7.77 (d, J = 2.8 Hz, 1H), 7.61 (d, J = 8.0 Hz, 1H), 7.42–7.32 (m, 2H), 7.28–7.21 (m, 1H), 7.14 (dd, J = 9.0, 2.8 Hz, 1H), 3.85 (s, 3H); 13 C NMR (DMSO- d 6 , 100 MHz) δ 159.93, 154.54, 141.05, 138.08, 132.76, 124.86, 124.45, 121.41, 121.24, 118.53, 117.81, 112.73, 112.08, 107.13, 104.60, 55.97; IR (KBr) 3191, 2999, 2834, 1635, 1559, 1516, 1456, 1401, 1231, 1125 cm –1 ; HRMS calcd for [C 16 H 12 N 2 O 2 – H + ]: 263.0826; found: 263.0820; CAS no. 649748-96-9 …”

Synthesis and anti-bacterial screening of ethyl 6-oxo-3-phenyl-1,6-dihydropyrano[3,2-e]indole-2-carboxylate and 7-phenyl-5H-pyrano [3′,2′:4,5]indolo[1,2-a]quinoxaline-6,10-dione

“…Coumarins constitute an important class of naturally occurring compounds with useful pharmacological activity [1][2][3][4][5][6] as antibacterial [7][8][9][10][11][12] and antifungal agents. [13][14][15][16][17] The result of the variety of the physiological activity of pyrroloindole derivatives [18][19] and also the possibility of their use in the synthesis of alkaloids and alkaloid related substances.…”