Synthesis of Hydroxypropylcellulose-poly(acrylic acid) Particles with Semi-Interpenetrating Polymer Network Structure

Abstract

To develop a novel type of semi-IPN particles using biocompatible materials, hydroxypropylcellulose-poly(acrylic acid) (HPC-PAA) particles with semi-interpenetrating polymer network structure and a porosity-structural surface were prepared by direct polymerization of acrylic acid monomer in the reaction system comprised of HPC and AA monomer and N,N'-methylenebisacrylamide (MBAAm). The properties of HPC-PAA gel particles were characterized by dynamic light scattering, FT-IR, transmission electron microscopy, and atomic force microscope. It is found that the formation of HPC-PAA gel particles is driven by the hydrogen bonding interaction between proton-donating PAA and proton-accepting HPC. These HPC-PAA gel particles exhibit thermo and pH dual-responsive behaviors. Depending on the chemical composition and the degree of cross-linking, the thermo-responsive property of HPC-PAA gel particles can be shifted from the UCST to the LCST property, and particle sizes can be changed from 100 to 1 microm in a controllable way. Successful loading of the gel particles with oxaliplatin, a hydrophilic antitumor drug, was achieved by take advantage of the complex interaction between the platinum atom of oxaliplatin and the carboxylic group of PAA in the gel particles. In vitro cytotoxicity assay indicates that the oxalipatin-loaded HPC-PAA gel particles have high anticancer activity. Considering the good biosafety, simple and mild preparation strategy and tunable size as well as the stimuli-responsive properties, the HPC-PAA gel particles should be a promising candidate for the drug delivery system.

A Facile Strategy for Constructing Boron‐Rich Polymer Nanoparticles via a Boronic Acid‐Related Reaction

“…The NPs with the feeding molar ratio glucopyranoside unit/APBA of 2/1 were then used for further investigation. Additionally, it was found that the Dextran-PAPBA NPs were obviously smaller than the reported uncrosslinked NPs generated by electrostatic or hydrogen bonding interactions, [11,12] which is attributable to the robust covalent linkage between dextran and PAPBA.…”

“…Non-covalent interactions, such as electrostatic and hydrogen bonding interactions, can also be used to impart amphiphilic character to biopolymers and fabricate NPs, whereas, the stability of the formed NPs is generally limited, especially in ionic, acidic and basic environments. [11,12] In contrast, the unique chemical properties of boronic acid make boronic acid-related reactions ideal candidates for constructing biopolymer-based NPs. Apart from diol, boronic acid can also react rapidly and reversibly with amino and carboxylic groups.…”

“…[14] Furthermore, the boronate ester binding can offer the NPs improved stability and smaller size compared to non-covalent interactions. [11,12] …”

Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

“…Hydrogen bonding interaction between hydroxyl groups of HPC and carboxyl groups of PAA induces the formation of HPC-PAA particles in the aqueous solution. The size of the templates can be readily tuned from 100-1000 nm by varying the feed ratio of HPC to AA from 10:1 to 1:2.5 [33]. In this study, the [HPC]:[AA] was fixed at 1:1.…”

“…Kozlovskaya group developed a series of weak polyacid based cross-linked capsules by hydrogen-bonded selfassembly as drug carriers [29][30][31]. In our previous work, various poly (acrylic acid) (PAA)-based micro/nanogels were prepared by using the precipitation polymerization method [32][33][34]. The obtained nanogels showed a high drug loading capacity and a sustained release feature for water-soluble drug molecules.…”